Intratympanic Glucocorticoids for Sudden Sensorineural Hearing Loss: A Systematic Review
Abstract: Objective To assess the efficacy and safety of intratympanic glucocorticoids for sudden sensorineural hearing loss. Methods We searched the Cochrane Library, PubMed, EMBASE, CBM,CNKI, and VIP databases and International Clinical Trials Registry website of World Health Organization using the key words “glucocorticoids”, “hearing loss” for the literatures of English and Chinese. Randomized controlled trials (RCTs) of intratympanic glucocorticoids versus placebo or intratympanic glucocorticoids versus controlled group（oral glucocorticoid/placebo）for sudden sensorineural hearing loss were included. According to the Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1, we assessed the quality of the included RCTs. A meta-analysis was carried out with the Cochrane Collaboration’s software RevMan 5.0.2. Results Five RCTs which contained 285 patients were included. Meta-analysis illustrated that there was sta-tistically significant on hearing recovery rate between the two groups (OR:3.94, 95% CI: 1.03-15.12). Hearing of pure tone average also improved significantly with intratympanic glucocorticoids therapy at 250HZ (p < 0.05). We found no statistically significant on the speech reception threshold (p = 0.20). Conclusion Com-pared with the control group, intratympanic glucocorticoids can significantly increase the hearing recovery rate of patients. Given the limitation of sample size of included studies into consideration, the results of this systematic review are still uncertain. Multi-center, large-scale, double-blinded randomized control trials are needed to confirm the available evidence.
文章引用: 杜婉 , 马彬 , 郭玉芬 (2011) 糖皮质激素鼓室给药治疗突发性聋的系统评价。 临床医学进展， 1， 1-4. doi: 10.12677/acm.2011.11001
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