GP73及其与肝癌诊断的研究进展
Advances in Research on GP73 and Its Diagnosis for Liver Cancer

作者: 朱源荣 * , 陆建华 :;

关键词: 高尔基体糖蛋白73肝癌诊断Golgi Protein 73 Liver Cancer Diagnosis

摘要:
高尔基体蛋白73(GP73)是一种新近发现的肝癌血清标志物。本文对GP73的结构、功能、表达及临床应用相关的研究进展作一综述,对其诊断肝癌的价值作出初步评价,并展望今后的发展重点和方向。
Golgi protein 73 (GP73) is a novel serum marker for the detection of liver cancer. This paper reviews the advances related in structure, functions, expression and clinical application of GP73, and eva- luates the values in the diagnosis for liver cancer. Prospective comments for the key points of development and the direction—in-the-future are also addressed.

文章引用: 朱源荣 , 陆建华 (2011) GP73及其与肝癌诊断的研究进展。 医学诊断, 1, 13-17. doi: 10.12677/md.2011.12003

参考文献

[1] 朱源荣, 陆建华, 王金兵等. 肝癌高发区不同人群乙肝及丙肝病毒标志物阳性率的变化[J]. 中国肿瘤, 2011, 20(6): 409- 412.

[2] 张涛, 单利. 高尔基体蛋白73与恶性肿瘤关系的研究进展[J]. 医学综述, 2010, 16(22): 3421-3423.

[3] 高松, 崔书, 巴明臣. GP73在肝癌诊断中的研究现状及前景[J]. 中华肝胆外科杂志, 2010, 16(12): 961-963.

[4] 王维林, 白鑫, 屠红. 肝癌血清标志物研究的新进展[J]. 肿瘤, 2009, 29(4): 389-393.

[5] 肖莉. GP73和肝脏疾病关系的研究进展[J]. 医学信息, 2010 23(11): 331.

[6] 谭龙益. Ⅱ型高尔基体膜蛋白与人类肝脏疾病的关系[J]. 中华肝脏病杂志, 2007, 15(2): 958-959.

[7] 李淑群, 陈谦. GP73与肝脏疾病关系的研究进展[J]. 世界华人消化杂志, 2010, 18(20): 2117-2120.

[8] 杨盛力, 潘晓莉. GP73的研究进展[J]. 肝胆外科杂志, 2011, 19(1): 70-72.

[9] R. D. Kladney, G. A. Bulla, L. Guo, et al. GP73, a novel Golgi- localized protein upregulated by viral infection. Gene, 2000, 249 (1-2): 53-65.

[10] S. Puri, C. Bachert, C. J. Fimmel, et al. Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal PH disruption. Traffic, 2002, 3(9): 641-653.

[11] R. Natarajan, A. D. Linstedt. A Cyclin Cis-Golgi Protein ma- diates endosme-to-Golgi traffic. Molecular Biology Cell, 2004, 15 (11): 4798-4806.

[12] C. Rabouile, E. Jokitalo. Golgi apparatus partition in during cell division. Molecular Memberance Biology, 2003, 20(2): 117-127.

[13] S. Mukherjee, R. Chiu, S. M. Leung, et al. Fragmentation of the Golgi apparatus an early apoptotic event in dependent of the Cytoskeleton. Traffic, 2007, 8(4): 369-378.

[14] C. Bachert, C. Fimmel and A. D. Linsted. Endosomal trafficking and Proprotein Convertase eleavage of Cis golgi protein GP73 produces marker for hepatocellular carcinoma. Traffic, 2007, 8: 1415-1423.

[15] J. S. Hu, D. W. Wu, S. Liang, et al. GP73, a resident Golgi glycoprotein, is Sensibility and specificity for hepatocellular car- cinoma of diagnosis in a hepatitis B-endemic Asian population. Medical Oncology, 2009, 27(2): 339-345.

[16] S. Varambally, B. Laxman, R. Mehra, et al. Golgi protein in GOLMI is a tissue and urine biomasker of prostate cancer. Neo- plasia, 2008, 10(11): 1285-1294.

[17] L. M. Wright, S. Yong, M. M. Picken, et al. Decreased survival and hepato-renal pathology in mice C-terminally truncated GP73 (GOLPH2). International Journal of Clinical Experimental Pa- thology, 2009, 2(1): 34-47.

[18] A. Maitra, P. J. Thuluvath. GP73 and liver disease: A (golgi) complex enigma. American Journal of Gastroenterology, 2004, 99: 1096-1098.

[19] F. R. Fritzsche, M. O. Riener, M. Dietel, et al. GOLPH2 expre- ssion in renal cell cancer. BMC Urology, 2008, 8: 15.

[20] D. Song, R. Chaerkdy, A. C. Tan, et al. Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor IP1-504 in Pancreatic Cancer. Molecular Cancer Therapeutics, 2008, 7(10): 3275-3284.

[21] F. R. Fritzsche, G. Kristiansen, M. O. Riener, et al. GOLPH2 expression may serve as diagnositic marker in seminomas. BMC Urology, 2010, 10: 4.

[22] M. O. Riener, F. Stenner, H. Liewen, et al. Golgi phosphoprotein 2(GOLPH2) experssion in liver tumors and its value as a serum marker in hepatocellular carcinomas. Hepatology, 2009, 49(5): 1602-1609.

[23] F. Zhang, et al. Upregulated Golgi phosphoprotein 2(GOLPH2) experssion in lung a denocarcinoma tissue. Clinical Biochemi- stry, 2010, 43(12): 983-991.

[24] R. D. Kladney, X. Gui, G. A. Bulla, et al. Expression of GP73, a resident golgi membrane protein, in viral and nonviral liver di- sease. Hepatology, 2002, 35(6): 1431-1440.

[25] R. D. Kladney, A. E. Tollefson, W. S. Wold, et al. Upregulation of the golgi protein GP73 by adenovirus infection requires the EIA CtBp interaction domain. Virology, 2002, 301: 236-246.

[26] R. Iftikhar, R. D. Kladney, N. Havlioglu, et al. Disease-and cell- specific expresesion of GP73 in human liver disease. American Journal of Gastroenterology, 2004, 99(6): 1087-1095.

[27] T. M. Block, M. A. Comanale, M. Lowman, et al. Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. National Proceeding Academy Sciences USA, 2005, 102(3): 779-784.

[28] J. A. Marrero, P. R. Romano, O. Nikolaeva, et al. GP73, a resident golgi glycoprotein is a novel serum marker for heap- tocellular carcinoma. Journal of Hepatology, 2005, 43(6): 1007- 1012.

[29] E. E. Schwegler, L. Cazares, L. F. Steel, et al. SELDI-TOF MS profiling of serum for detection of the progression of chronic hepatitis C to hepatocellular carcinoma. Hepatology, 2005, 41: 634-642.

[30] S. Srivastava. Cancer biomarker discovery and development in gastrointestinal cancers: Early detection research network—A co- llaborative approach. Gastrointest Cancer Research, 2007, 1 (Suppl. 2): S60-3.

[31] C. Willyard. Researchers look for “sweet” method to diagnosis Cancer. Nature Medicine, 2007, 13(11): 1267-1269.

[32] S. Benowitz. Liver cancer biomarkers struggling to succeed. Journal of Nationall Cancer Institute, 2007, 99(8): 590-591.

[33] W. Cassandra. Rosearchers look for “sweet” method to diagnose Cancer. Nature Medicine, 2007, 13: 1267.

[34] 毛一雷, 杨华瑜, 徐海峰等. 新的肝癌血清标记物GP73在肝癌诊断中的初步研究[J]. 中华医学杂志, 2008, 88(14): 948- 951.

[35] 徐海峰, 杨华瑜, 张宏冰等. 改变肝癌早期诊断和治疗现状的新肝癌血清标志物[J]. 基础医学与临床, 2008, 28(1): 104-108.

[36] 李利军, 李新丰, 王高雄. GP73联合AFP、VEGF 检测对原发性肝癌的诊断价值[J]. 世界华人消化杂志, 2009, 17(29): 3056-3060.

[37] Y. Mao, H. Yang, H. Xu, et al. Golgi protein 73(GOLPH2) is a valuable serum marker for hepatocellula carcinoma. Gut, 2010, 59(12): 1687-1693.

[38] 付超, 齐军, 李学禅等. 高尔基体蛋白(GP73)检测在肝细胞癌中的应用价值[J]. 中国肿瘤, 2010, 19(8): 553-556.

[39] 赵秀英, 李英, 丁惠国等. 血清高尔基体糖蛋白73在肝细胞癌诊断中的作用[J]. 中华肿瘤杂志, 2010, 32(12): 943-946.

[40] 张祖平, 张德忠, 吴耀震. 血清GP73联合AFP对PHC的早期诊断价值探讨[J]. 放射免疫学杂志, 2010 23(2): 205-206.

[41] 张亚松, 石玉玲 张喜欽. GP73在肝癌早期诊断中的应用价值[J]. 医学临床研究, 2011, 28(4): 651-653.

[42] 梁冠林, 廖志学, 冉顺等. 血清GP73在肝脏肿瘤中的表达及意义[J]. 中华普通外科杂志, 2010, 25(4): 339-340.

[43] 李淑群, 陈谦, 喻亚群等. 肝细胞肝癌组织中GP73的表达变化[J]. 山东医药, 2011, 51(2): 60-61.

[44] 刘树业, 杜智, 邵新华等. 高尔基体蛋白73在肝癌诊断中的意义[J]. 广东医学, 2010, 31(3): 309-311.

[45] 石玉玲, 曾兰兰, 李林海等. 高尔基体蛋白73及其基因检测对原发性肝癌诊断的价值[J]. 中华检验医学杂志, 2010, 33(6): 507-512.

[46] 朱国民, 周晓庆, 林长青等. 新肝癌标志物高尔基体蛋白GP73在肝癌血清诊断中的应用[J]. 中华医院感染学杂志, 2010, 20(15): 2350-2352.

[47] 陈文莉, 彭涛, 陈小苹等. 血清GP73检测在肝脏疾病诊断中的临床意义[J]. 中华检验医学杂志, 2010, 33(4): 333-336.

[48] 谭龙益, 陈洁, 王皓. 血清Ⅱ型高尔基体膜蛋白与人类肝细胞癌的关系[J]. 中华肝脏病杂志, 2009, 17: 288-291.

[49] M. S. Pepe, R. Etzioni, Z. Feng, et al. Phases of biomark de- velopment for early detection of cancer. Journal of Nationall Cancer Institute, 2001, 93(14): 1054-1061.

[50] R. R. Darke, E. E. Schwegler, G. Malik, et al. Lectin capture strategies combined with mass spectrometry for the discovery of serum glycoprotein biomarkers. Molecular Cell Proteomics, 2006, 5(10): 1957-1967.

分享
Top