鼻咽癌早期诊断的现状及进展
Status and Progress of Nasopharyngeal Carcinoma Early Diagnosis

作者: 蒋中秀 , 伦永志 :;

关键词: 鼻咽癌早期诊断检测技术Nasopharyngeal Carcinoma Early Diagnosis Measurement Technology

摘要:
鼻咽癌是我国南部和东南亚地区常见的癌症之一,严重影响人类的健康。由于鼻咽部位较深且位置隐蔽,以致鼻咽癌早期症状和体征不明显,容易漏诊、误诊,延误最佳治疗时机,因此能够早期诊断鼻咽癌,对于提高治疗效果和患者生存率非常关键。
Nasopharyngeal carcinoma is one common form of cancer in Southern China and Southern Asia, serious impact on human health. Because of the deeper parts and the hidden location of nasopharynx, it was not obvious to find early signs and sysptoms, then it was easy to misdiagnosis and delay the optimal time of treatment. Therefore, it is very important to early diagnosis of nasopharyngeal carcinoma for improving the treatment and patient survival.

文章引用: 蒋中秀 , 伦永志 (2011) 鼻咽癌早期诊断的现状及进展。 医学诊断, 1, 7-12. doi: 10.12677/md.2011.12002

参考文献

[1] A. K. F. Lo, K. W. Lo, S. W. Tsao, et al. Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells. Neoplasia, 2006, 8(3): 173-180.

[2] K. W. Lo, K. F. To and D. P. Huang. Focus on nasopharyngeal carcinoma. Cancer Cell, 2004, 5(5): 423-428.

[3] W. T. Ng, C. W. Choi, M. C. Lee, et al. Outcomes of naso- pharyngeal carcinoma screening for high risk family members in Hong Kong. Fam Cancer. 2010, 9(2): 221-228.

[4] C. W. Choi, M. C. Lee, W. T. Ng, et al. An analysis of the effi- cacy of serial screening for familial nasopharyngeal carcinoma based on Markov chain models. Fam Cancer, 2011, 10(1): 133- 139.

[5] T. W. Wang, H. Y. Lu, P. J. Lou, et al. Application of highly sensitive, modified glass substrate-based immuno-PCR on the early detection of nasopharyngeal carcinoma. Biomaterials, 2008, 29(33): 4447-4454.

[6] D. K. Paramita, J. Fachiroh, S. M. Haryana, et al. Two-step Epstein-Barr virus immunoglobulin a enzyme-linked immuno- sorbent assay system for serological screening and confirmation of nasopharyngeal carcinoma. Clinical and Vaccine Immunology, 2009, 16(5): 706-711.

[7] Y. Q. Tong, Z. J. Zhang, B. Liu, et al. Autoantibodies as po- tential biomarkers for nasopharyngeal carcinoma. Proteomics, 2008, 8(15): 3185-3193.

[8] Y. S. Wei, Y. H. Zheng, W. B. Liang, et al. Identification of se- rum biomarkers for nasopharyngeal carcinoma by proteomic ana- lysis. Cancer, 2008, 112(3): 544-551.

[9] X. W. Huang, W. Zhou, J. Chen, et al. A pilot investigation on serum protein fingerprinting of nasopharyngeal carcinoma. Chi- nese Journal of Otorhinolaryngology Head and Neck Surgery, 2011, 46(6): 509-512.

[10] G. Henle, W. Henle. Epstein-Barr virus-specific IgA serum an- tibodies as an outstanding feature of nasopharyngeal carcinoma. International Journal of Cancer, 1976, 17(1): 1-7.

[11] S. M. Cao, Z. Liu, W. H. Jia, et al. Fluctuations of epstein-barr virus serological antibodies and risk for nasopharyngeal carcinoma: A prospective screening study with a 20-year follow-up. PLoS One, 2011, 6(4): e19100.

[12] Y. Liu, Q. Huang, W. Liu, et al. Establishment of VCA and EBNA1 IgA-based combination by enzyme-linked immuno- sorbent assay as preferred screening method for nasopharyngeal carcinoma: A two-stage design with a preliminary performance study and a Mass screening in southern china. International Jour- nal of Cancer, 2011, Online Version of Record Published before Inclusion in an Issue.

[13] S.-Q. Jiang, Q. Liu. Application of logistic regression in com- bination with multiple diagnostic tests for auxiliary diagnosis of nasopharyngeal carcinoma. Chinese Journal of Cancer, 2009, 28 (2): 177-180.

[14] 罗耀凌, 欧国萍, 池沛东等. 联合检测EB病毒相关抗体和抗原对诊断鼻咽癌的价值[J]. 癌症, 2009, 28(1): 96-99.

[15] H. Zheng, L. L. li, D. S. Hu, et al. Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of na- sopharyngeal carcinoma. Cellular & Molecular Immunology, 2007, 4(3): 185-196.

[16] S. P. Hao, N. M. Tsang and K. P. Chang. Screening naso- pharyngeal carcinoma by detection of the latent membrane pro- tein 1 (LMP-1) gene with nasopharyngeal swabs. Cancer, 2003, 97(8): 1909-1913.

[17] S. P. Hao, N. M. Tsang, K. P. Chang, et al. Molecular diagnosis of nasopharyngeal carcinoma: detecting LMP-1 and EBNA by nasopharyngeal swab. Otolaryngology Head Neck Surgery, 2004, 131(5): 651-654.

[18] J. H. Tong, R. K. Tsang, K. W. Lo, et al. Quantitative Epstein- Barr virus DNA analysis and detection of gene promoter hyper- methylation in nasopharyngeal(NP) brushing samples from pa- tients with NP carcinoma. Clinical Cancer Research, 2002, 8(8): 2612-2619.

[19] S. F. Leung, J. S. Tam, A. T. Chan, et al. Improved accuracy of detection of nasopharyngeal carcinoma by combined application of circulating Epstein-Barr virus DNA and anti-Epstein-Barr viral capsid antigen IgA antibody. Clinical Chemistry, 2004, 50(2): 339- 345.

[20] R. Dardari, W. Hinderer, D. Lang, et al. Antibody responses to recombinant Epstein-Barr virus antigens in nasopharyngeal car- cinoma patients: Complementary test of ZEBRA protein and early antigens p54 and p138. Journal of Clinical Microbiology, 2001, 39(9): 3164-3170.

[21] 汤敏中, 郑裕明, 蔡永林等. ZEBRA/IgG抗体检测在鼻咽癌血清学诊断中的应用[J]. 肿瘤防治研究, 2007, 34(5): 394.

[22] P. Feng, E. C. Ren, D. Liu, et al. Expression of EBV lytic gene BRLF1 in nasopharyngeal carcinoma:potential use in diagnosis. Journal of Genetic Virology, 2000, 81(10): 2417-2423.

[23] Y. Conolly, E. Littler, N. Sun, et al. Antibodies to Epstein-Barr virus thymidine kinase:a characteristic marker for the serological detection of nasopharyngeal carcinoma. International Journal of Cancer, 2001, 91(5): 692-697.

[24] S. H. Hutajulu, S. R. Indrasari, L. P. Indrawati, et al. Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population. Mol Cancer, 2011, 10: 48.

[25] H. D. Zhou, G. Y. Li, Y. X. Yang, et al. Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carci- noma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain. Mol Immunology, 2006, 43(11): 1864- 1871.

[26] 倪海峰, 莫颖禧, 周晓莹等. P14ARF和p16 INK4a基因在鼻咽癌组织中异常甲基化及其临床意义[J]. 广西医科大学学报, 2008, 25(3): 341-343.

[27] 倪海峰, 黄光武, 张哲等. p27基因甲基化在鼻咽癌发生发展中的作用[J]. 解放军医学杂志, 2010, 35(2): 147-150.

[28] K. W. Lo, J. Kwong, A. B. Hui, et al. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Can- cer Research, 2001, 61(10): 3877-3881.

[29] J. Kwong, K. W. Lo, K. F. To, et al. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clinical Cancer Research, 2002, 8(1): 131-137.

[30] D. Sun, Z. Zhang, N. Van do, et al. Aberrant methylation of CDH13 gene in nasopharyngeal carcinoma could serve as a po- tential diagnostic biomarker. Oral Oncology, 2007, 43(1): 82- 87.

[31] 张文玲, 周艳宏, 肖岚等. 鼻咽癌分子标志物研究[J]. 生物化学与生物物理进展, 2008, 35(1): 7-13.

[32] C. Maohuai, A. R. Chang and L. Shikyuen. Roles of DNA cy- tometry and detection of EBERs in predicting a diagnosis of na- sopharyngeal carcinoma. Anal Quant Cytology Histology, 2002, 23(3): 207 -212.

[33] S. Q. Fan, J. Ma, J. Zhou, et al. Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and naso- pharyngeal carcinoma using tissue microarray analysis. Human Pa- thology, 2006, 37(5): 593-605.

[34] M. L. He, M. X. Luo, M. C. Lin, et al. MicroRNAs: Potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma. Biochemica et Biophysica Acta, 2011, 1825(1): 1-10.

分享
Top