The Effect of Plastic Deformation of Stainless Steel Stent on the Behavior of Vascular Wall Cells
Abstract: Metal stents are widely used in interventional therapy of cardiovascular diseases. The amount of plastic deformation is different in each position when the stent is expanded in the vessel. When the stent is in direct contact with the cells of the vessel wall and interacts with them, the amount of plas-tic deformation of the metal will affect the behavior of the cells of the vessel wall. Based on this, this paper takes biomedical stainless steel as the object, and sets different amounts of deformation (20%, 60%, 100%) for the plastic deformation of stent after expansion. The universal testing machine was used to stretch the biomedical stainless steel. The surface morphology of the samples was characterized by optical microscope (OM), scanning electron microscope (SEM) and step measuring instrument. The physical and chemical properties of the surface of the sample were measured by water contact angle (WCA) the calculation of surface energy component. The growth behavior of the cells of the vessel wall was evaluated by fluorescence staining and cell counting kit-8 (CCK-8). The results show that the endothelial cells have the best activity when the deformation is 60%, but the smooth muscle cells have no significant difference. When the deformation is more than 60%, the growth direction of endothelial cells and smooth muscle cells tend to be parallel to the stretching direction. The results of this study suggest that it is of great significance to design the appropriate configuration of the stent, as it can adjust the plastic deformation of different positions of the stent during the service process, and improve the cell behavior on the vascular wall.
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