The Research Progress and Application Prospect of Uncoupling Protein 1 (UCP1)
Abstract: UCP1 is the only one expression of uncoupling protein in the brown adipose tissue (BAT). Different from the uncoupling protein family other member functions, UCP1’s main function is to participate thermogenic regulation and energy metabolism in BAT to maintain the body’s energy metabolic balance. In succession studies clarify regulation UCP1 participate heat production regulation and energy metabolism molecular mechanism in BAT, gradually reveals the UCP1 inBAT energy metabolic process involved in the signal path and transcription regulation. This not only let us better understand UCP1 inBAT energy metabolism control of the important role, but based on brown adipose tissue obesity treatment provides a theoretical basis. This paper describes the research in recent years UCP1 found in BAT energy metabolism process play an important role in the signal path and transcription regulation, and discussed based on various for brown adipose tissue obesity treatment of the effectiveness and feasibility.
文章引用: 高文荣 , 张 麟 , 余婷婷 , 朱万龙 , 王政昆 (2012) 解偶联蛋白-1(UCP1)的研究进展及其应用前景。 生物过程， 2， 128-137. doi: 10.12677/BP.2012.23021
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