The Research Progress on the Heterogeneity of Bipolar Disorder and Major Depressive Disorder

作者: 李金灵 * , 许海云 :汕头大学医学院精神卫生中心,广东 汕头;

关键词: 双相障碍重性抑郁障碍异质性诊断Bipolar Disorder Major Depressive Disorder Heterogeneity Diagnosis


Abstract: Bipolar disorder (BD) and Major Depressive Disorder (MDD) are two common mood disorders with significant impacts on human health and heavy economic burdens on governments and pa-tients’ families. In clinical practice, it is very difficult to distinguish BD from MDD as the BD pa-tients in depressive episode stage may manifest the same symptoms as those of MDD patients. There is increasing research evidence, however, showing the differences between MDD and BD in multiple aspects, such as clinical characteristics and pathogenesis. Here, we summarized the research progress on the heterogeneity of BD and MDD by reviewing Chinese and English literature published in recent years. The main content includes the differences between the both disorders in clinical manifestations, psychological characteristics, genetic factors, neuropathology, and neurochemical metabolism. These data would be useful for the early identification of BD from MDD.

文章引用: 李金灵 , 许海云 (2017) 双相障碍和重性抑郁障碍疾病异质性研究进展。 心理学进展, 7, 978-987. doi: 10.12677/AP.2017.78122


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