Advances of cGAS

作者: 辛佳静 , 郭晓敏 , 孟 丽 , 汲广东 :中国海洋大学海洋生命学院,海洋生物多样性与进化研究所,山东 青岛;

关键词: cGASDNA感受器STING免疫进化cGAS DNA Sensor STING Immune Evolution

环鸟苷酸-腺苷酸合成酶(cyclic GMP-AMP synthase, cGAS)是一种核酸转移酶,在哺乳动物中具有DNA 感受器的功能,能识别胞质DNA并产生cGAMP (cyclic GMP-AMP),激活干扰素刺激蛋白(stimulator of interferon genes, STING),调控下游的I型干扰素(interferon, IFN)和其他细胞因子的分泌,启动机体的免疫反应。cGAS不仅能够抗病毒,也能抵抗细菌的感染。结构上,cGAS由氨基端的DNA结合位点,中间的催化结构域以及羧基端保守的Mab-21 (male abnormal 21)结构域组成,属于MAB21家族蛋白。进化分析发现,脊椎动物的cGAS来源于祖先Mab-21结构域,并且在鱼类和某些哺乳动物中通过基因组复制产生了cGAS和cGASL基因。本文就cGAS结构和免疫功能的研究进展以及演化情况进行了综述。

Abstract: cGAS (cyclic GMP-AMP synthase), a kind of nucleic acid transferase and one of the latest DNA sensors being found in mammals, could identify DNA in cytoplasm and produce cGAMP (cyclic GMP-AMP) to activate interferon stimulated gene (STING), then activate the type I interferon and other cytokines to execute immune function. It was found that cGAS could not only be involved in antiviral response, but also in antibacteria response. cGAS is composed of DNA binding site in N-terminal, a central catalytic domain and a conserved Mab-21 (male abnormal 21) domain in C-terminus, which belongs to MAB21 family protein. Phylogenetic analysis showed that vertebrate cGAS is derived from ancestral Mab-21 domain, which also produced cGAS-like gene through genome duplication in fishes and some mammals. In this review, we discussed the recent research progress regarding the role of cGAS in immune response and its evolution scenario.

文章引用: 辛佳静 , 郭晓敏 , 孟 丽 , 汲广东 (2017) cGAS的研究进展。 海洋科学前沿, 4, 61-67. doi: 10.12677/AMS.2017.42009


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