维生素C及其衍生物在药物及载体靶向修饰中的应用
The Application of Ascorbic Acid and Its Derivatives in Targeting Modification of Prodrug and Drug Delivery Carrier

作者: 胡思源 * , 易芳莲 , 栾立标 :中国药科大学药剂学实验室,江苏 南京;

关键词: 维生素C靶向药物结构修饰载体靶向修饰Ascorbic Acid Targeted Prodrug Modification Targeted Drug Delivery Modification

摘要:
维生素C作为天然抗氧化剂以及体内代谢的重要辅酶,用途广泛,近年来因其作为前药靶向修饰剂备受关注。本文对近年来国内外相关研究文献进行分析、归纳,总结维生素C及其衍生物在药物及载体靶向修饰中的应用,以期为合理设计靶向药物分子提供思路和方法。

Abstract: As a nature antioxidant and an important conferment involved in the metabolism, ascorbic acid is commonly used and has gained immense attention recently for its targeting ability. In the present article, we reviewed and summarized relevant research that investigated the potential of ascorbic acid and its derivatives to act as targeting ligand while being modified into prodrug and drug delivery carrier, and we look forward to providing the proper construction of targeting drug delivery system with new prospective and methods.

文章引用: 胡思源 , 易芳莲 , 栾立标 (2017) 维生素C及其衍生物在药物及载体靶向修饰中的应用。 药物资讯, 6, 17-24. doi: 10.12677/PI.2017.62004

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