Anti-Aging Substances from Maca Supercritical Extract
Abstract: Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural compound 1 from spectroscopic data and biological activity.
文章引用: 程丽红 , 林燕飞 , 王艳惠 , 朴金株 , 金泰硕 , 向 兰 , 吕翼炫 , 戚建华 (2017) 玛咖超临界提取物中的抗衰老活性物质。 有机化学研究， 5， 45-50. doi: 10.12677/JOCR.2017.51007
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