Association between Tef rs738499 Gene Polymorphism with Different Subtypes of Depression in Parkinson’s Disease
Abstract: Objective: To investigate the association between Tef rs738499 gene polymorphism and depression in different subtypes of Parkinson’s disease in China’s northern Han nationality. Methods: A case-control study design was adopt in the 230 patients with Parkinson’s disease (PD group) and 250 healthy control subjects (control group). According to exercise symptoms and UPDRS score, PD group was divided into three types: Tremor type, postural disorder type and uncertainty type. PD patients were divided into depression group (PDD group, n = 116) and non-depression group (non-PDD, n = 114) according to HAMD score. Polymerase chain reaction combined with restriction endonuclease polymorphism (PCR-RFLP) were used to detect and sequence the distribution of Tef rs738499 allele and genotype. Results: (1) Compared with the control group, the allele of the T allele had no significant difference in the PD group (OR: 0.983 95% CI: 0.720 - 1.342 P = 0.913). There was no significant difference in wild type genotype that is TT genotype in the PD group (OR: 0.931 95% CI: 0.646 - 1.340 P = 0.699); (2) after PD patients were divided into PDD and n-PDD group, T allele between the two groups had statistically significant difference. T allele risk of occurrence PDD was 3.0 times more likely than the n-PDD group’s occurrence in G allele (OR: 2.975 95%CI: 1.838 - 4.815 P < 0.01). And the wild type genotype was statistically significant different between the two groups. The occurrence of PDD risk in TT genotype was 4.6 times higher than that of TG + GG (OR: 4.646 95% CI: 2.637 - 8.186 P <0.01); (3) there was significant difference between PDD group and n-PDD group in the three subtypes of TT genotype; (4) course of disease, UPDRS-III score, Tef rs738499 TT genotype were an independent risk factor for PDD. Conclusion: Tef rs738499 TT genotype and T allele are associated with different subtypes of Parkinson’s disease in Han nationality in northern China.
文章引用: 黄 樊 , 潘旭东 , 厉 娜 , 马爱军 (2017) Tef rs738499基因多态性与帕金森病不同亚型合并抑郁的相关性。 临床医学进展， 7， 23-29. doi: 10.12677/ACM.2017.71005
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