Clinical Comparative Study about Intra-Articular Injection of Tranexamic Acid with Different Drainage Tube Clamping Time after Total Knee Arthroplasty
Abstract: [Background] Topical application of tranexamic acid in reducing blood loss after total knee arth-roplasty is clinically recognized. But systematic studies about intra-articular injection of tranex-amic acid of drainage tube clamping time after total knee arthroplasty are rarely. [Objective] To explore the effects of intra-articular injection of tranexamic acid with different drainage tube clamping time after total knee arthroplasty to postoperative blood loss, blood transfusion and complications. To select the optimal drainage tube clamping time about intra-articular injection of tranexamic acid after total knee arthroplasty. [Methods] Retrospective analysis of 152 patients with knee osteoarthritis admitted to the Affiliated Hospital of Qiingdao University from January 2015 to March 2016. 152 patients were performed primary total knee arthroplasty. Injection of TXA injection (50 ml, 40 mg/ml) into the articular cavity via syringe after suture of joint capsule and clamped drainage tube, then bandage compression knee joint, release tourniquet. 152 patients were randomly divided into 4 groups according to the duration of the closure of the drainage tube (clipping 1 h group, clamping 2 h group, clamping 3 h group, clamping 4 h group), each group included 38 patients. The amount of intraoperative blood loss, total blood loss, postoperative visible blood loss and hidden blood loss was calculated. Postoperative blood transfusion, limb subcutaneous ecchymosis, knee swelling and limb muscular venous thrombosis number were counted. Knee Hospital for Special Surgery score was evaluated at 6 months after replacement. [Results] In terms of total blood loss, postoperative visible blood loss and hidden blood loss, postoperative blood transfusion rate, clamping 3 h group, clamping 4 h group were significantly lower than that of clipping 1 h group, clamping 2 h group, and clamping 2 h group was significantly lower than that of clipping 1 h group. Postoperative limb subcutaneous ecchymosis, knee swelling incidence of clamping 4 h group increased significantly. There was no significant difference in the HSS score between the 4 groups at 6 months postoperatively. [Conclusion] Clamping drainage tube for 3 h is the best choice about intra-articular injection of tranexamic acid after total knee arthroplasty.
文章引用: 潘 飞 , 张才龙 , 黄 辉 , 杨选影 , 夏长所 (2016) 全膝关节置换术后氨甲环酸关节腔内注射不同引流管夹闭时间的临床对比研究。 外科， 5， 81-88. doi: 10.12677/HJS.2016.54014
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