Relationship between Serum Sialic Acid Concentration and Macular Edema in Patients with Type 2 Diabetes Mellitus Treated with Panretinal Photocoagulation
Abstract: Objective: To explore the association between serum sialic acid concentration and macular edema in patients with type 2 Diabetes mellitus treated with panretinal photocoagulation (PRP). Method： A total of 102 type 2 Diabetes mellitus patients with III-IV diabetic retinopathy but without macular edema were enrolled. They were treated with 4 times of panretinal photocoagulation by the same physician and the occurrence of macular edema was recorded. Then used the peripheral venous blood to test the serum sialic acid by colorimetry and graded the macular edema based on fundus fluorescein angiography (FFA). Result: The mean serum sialic acid concentration of 102 diabetes patients was 106.65 ± 10.21 mmol/l. 22 patients had macular edema after the PRP treatment, including ten with Grade 1 macular edema, five with Grade 2 macular edema and seven with Grade 3 macular edema. The mean serum sialic acid concentration of the patients without and with macular edema was 96.33 ± 10.39 mmol/l and 120.01 ± 17.71 mmol/l, respectively. The difference was statistically (P < 0.05). There was a significant positive correlation between the serum sialic acid concentration and maclar edema grade (r = 0.68, P < 0.05). Conclusion: Serum sialic acid concentration was closely related to the occurrence of macular edema in type 2 Diabetes mellitus patients treated with PRP.
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