低分子肝素钙对恶性肿瘤患者D-二聚体和PICC管堵塞的影响
Effect of Low Molecular Weight Heparin on D-Dimer and PICC Tube Blockage of Malignant Cancer Patients

作者: 陈雅萍 , 顾枫琳 , 华棋燕 , 董柏年 :浙江萧山医院,浙江 杭州;

关键词: 低分子肝素钙恶性肿瘤D-二聚体PICC导管Low Molecular Weight Heparin Malignant Cancer D-Dimer PICC Tube

摘要:
目的:探讨低分子肝素钙对恶性肿瘤患者D-二聚体和PICC管堵塞的影响,及抗凝治疗对PICC导管堵塞的干预效果。方法:选择D-二聚体偏高并置有PICC导管的恶性肿瘤患者30例,随机分为两组,测定15例(治疗组)接受低分子肝素钙治疗后D-二聚体的变化,同时检测15例(对照组) D-二聚体值进行对比观察。结果:与治疗前比较,低分子肝素治疗组在治疗后的2、4和7天的降低率为49.22%、50.18%和61.92%;对照组患者的D-二聚体在治疗后2、4和7天的降低率为6.00%、22.13%和13.57%。治疗组的下降率高于对照组。同时,低分子肝素治疗组抗凝后出现1例PICC导管堵塞,堵管率为6.67%,对照组出现10例PICC导管堵塞,堵管率为66.67%。结论:恶性肿瘤患者存在血液高凝及凝血功能紊乱,经低分子肝素钙治疗后可明显改善症状,降低血浆D-二聚体水平,同时减少PICC导管的堵塞,值得临床推广和应用。

Abstract: Objective: To investigate the effect of low molecular weight heparin in patients with cancer D- dimer and PICC tube blockage, and anticoagulation effect of interference PICC catheter blockage. Methods: D-dimer High malignancy in patients with PICC catheter 30 patients were randomly divided into two groups, measured 15 cases (treatment group) accept change after low molecular weight heparin therapy D-dimer, while detected 15 cases (control group) D-dimer values were compared. Results: The treatment with relatively low molecular weight heparin in the treat- ment group at 2, 4 and 7 days after treatment reduced rate of 49.22%, 50.18% and 61.92%; the control group of patients after treatment 2,4 D-dimer and 7 days reduced rate of 6.00%, 22.13% and 13.57%. The rate of decline in treatment group is higher than the control group. Meanwhile, the low molecular weight heparin anticoagulant therapy group 1 case PICC catheter blockage, plugging rate of 6.67% in the control group had 10 cases of PICC catheter obstruction, plugging rate was 66.67%. Conclusion: Cancer patients hypercoagulable and coagulation disorders, the low molecular weight heparin treatment can significantly improve symptoms, reduce plasma D-dimer levels, while reducing the PICC catheter blockage, worthy of promotion and application.

文章引用: 陈雅萍 , 顾枫琳 , 华棋燕 , 董柏年 (2016) 低分子肝素钙对恶性肿瘤患者D-二聚体和PICC管堵塞的影响。 临床医学进展, 6, 128-131. doi: 10.12677/ACM.2016.63023

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