一氧化氮和天然抗氧化剂对阿尔茨海默症的潜在防治作用
Preventive and Therapeutic Effects of Nitric Oxide and Natural Antioxidants on Alzheimer’s Disease
作者: 陈梦媛 , 李 超 , 赵 燕 :哈尔滨工业大学(威海)生物工程系,山东 威海; 张 娟 , 刘 强 :中国科学技术大学生命科学学院,中科院脑功能与脑疾病重点实验室,安徽 合肥; 张智贤 , 徐 力 :吉林大学生命科学学院,吉林 长春 ;
关键词: 一氧化氮; 天然抗氧化剂; 阿尔茨海默症; 活性氧; Nitric Oxide; Natural Antioxidants; Alzheimer’s Disease; Reactive Oxygen Species
摘要:Abstract: In this study, the preventive and therapeutic potential of nitric oxide (NO) and natural antioxidants on Alzheimer’s disease (AD) were studied using transgenic cells and C. elegans models. It was found that low concentration of NO protected neuronal cells by reducing the production of reactive oxygen species (ROS). In contrast, high concentration of NO aggravated the cell damage by producing more ROS. Low concentration of NO and natural antioxidant could protect C. elegans against paralysis induced by expression of transgenic Abeta gene. It was found that a formulation of L-arginine and natural antioxidants increased the viability of N2a cells overexpressing APPsw and ApoE4 by scavenging ROS. This formula also protected C. elegans against paralysis caused by transgenic Abeta gene. These results suggest that this formulation of NO precursor and natural antioxidants may have a potential for prevention and treatment of AD.
文章引用: 陈梦媛 , 张 娟 , 李 超 , 张智贤 , 徐 力 , 刘 强 , 赵 燕 (2016) 一氧化氮和天然抗氧化剂对阿尔茨海默症的潜在防治作用。 食品与营养科学, 5, 105-113. doi: 10.12677/HJFNS.2016.53014
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