Analysis of Prognostic Factors in 168 Cases of Lung Adenocarcinoma Patients Treated with Targeted Therapy Combined with Chemotherapy
Abstract: Objectives: The subject of this study is to investigate whether the lung adenocarcinoma patients accept chemotherapy and the cycles of chemotherapy, whether they accept radiotherapy, whether they have received targeted therapy and what specific targeted drugs they used and the effect on prognosis, aiming to find out the influential clinical factors in the prognosis of lung adenocarcinoma in order to provide a theoretical basis to carry out individualized treatment and prolong the survival time of the patients. Methods: 168 Patients who first received treatment from January 2010 to December 2012 in the first hospital of Qinhuangdao and diagnosed through pathological science examination with lung adenocarcinoma were enrolled. These patients do not have other serious underlying diseases and have never received any anti-tumor therapy. Statistical data are analyzed by SPSS17.0. Kaplan-Meier survival analysis and Log-rank test analysis are applied to compare the influences of clinical features on the prognosis. Cox regression model is used for multivariate analysis to identify independent factors of prognosis in patients with lung adenocarcinoma. The difference value of P < 0.05 is considered statistically significant. Result: It is found through single factor analysis that whether they have received surgical treatment or chemotherapy, the number of chemotherapy cycles, and whether targeted treatment has been applied to them have effect on the prognosis of lung adenocarcinoma patients (P value < 0.05). In contrast, little effects can be found in factors such as patient’s age when diagnosed, gender, whether they smoke or not, the number of cigarettes they smoke, family history of malignant tumor, experience of radiotherapy (P value > 0.05). Statistical analysis showed that there were no significant differences in the median survival time between who took TKI drugs, who used anti-angiogenesis drugs and who used both of the drugs (P = 0.230). There were significant differences in the median survival time between who received targeted treatment alone, who received targeted treatment and chemotherapy, who received targeted treatment and radiotherapy and who received targeted treatment, chemotherapy and radiotherapy (P = 0.020). Cox proportional hazards model showed that the independent factors affecting the prognosis of lung adenocarcinoma included: whether patients received chemotherapy or not, chemotherapy cycles, whether patients received targeted therapy (P < 0.05). Conclusion: Chemotherapy and targeted therapy are independent prognostic factors in patients with lung adenocarcinoma. Targeted therapy helps to improve the prognosis in patients with lung adenocarcinoma. The combination of targeted therapy, chemotherapy and radiotherapy can prolong the survival time for patients with lung adenocarcinoma.
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