Establishment of Skin Scald Model in Mice
Abstract: To establish an animal model in mice for the drug development with skin scald. After the anesthe-tization BABL/c mice were scalded in a 1 cm-diameter circle area on the dorsum by boiling water at contact time 10 s. The mice were sacrificed at 1, 7, 14 and 21 days after scald. The skin samples were collected and analyzed by histopathological examinations. Histological observation showed a II degree injury involving full-thickness skin in the 1 d mice group. Tissue necrosis and inflammatory reaction were observed in the 7 d mice group. Granulation tissue hyperplasia began to appear in the 14 d and 21 d mice group. All the results showed that a mice skin scald model was successfully established which is stable and can be used on the drug development for the damaged skin in future research.
文章引用: 康静静 , 焦 哲 , 苏博威 , 张金花 , 李慧平 (2016) 小鼠皮肤烫伤模型的建立。 亚洲兽医病例研究， 5， 15-19. doi: 10.12677/ACRPVM.2016.53004
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