两种新型三甲基硅乙基葡萄糖苷的合成与表征
Synthesis and Characterization of Two Novel 2-(Trimethylsilyl)ethyl Glucosides

作者: 乐 晗 :遵义医学院药学院,贵州 遵义; 金 笑 , 向学慧 :浙江中医药大学药学院,浙江 杭州 ; 丁 侃 , 曲欢欢 :中国科学院受体结构与功能重点实验室,中国科学院上海药物研究所,上海;

关键词: 葡萄糖苷核磁共振结构表征合成Glucosides NMR Structure Elucidation Synthesis

摘要:
本文报道了化学方法高效合成两种新型三甲基硅乙基葡萄糖苷的策略,所合成的化合物结构分别经高分辨质谱、一维和二维核磁共振谱确证。该两种新型葡萄糖苷作为寡糖合成的单糖砌块,可为未来我们构建新的寡糖结构片段提供物质基础和技术参考。

Abstract: Two novel 2-(trimethylsilyl)ethyl glucosides have been synthesized by a short and efficient route starting from D-Glucose. Their structures were elucidated by applying high-resolution mass spectra, one-dimensional and two-dimensional NMR techniques. These glucosides were prepared and used as intermediate building blocks in the scheme developed for oligosaccharide construction.

文章引用: 乐 晗 , 金 笑 , 向学慧 , 丁 侃 , 曲欢欢 (2016) 两种新型三甲基硅乙基葡萄糖苷的合成与表征。 有机化学研究, 4, 33-39. doi: 10.12677/JOCR.2016.42005

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