Analysis on Treatment Effect of Severe AOPP Combining Penehyclidine Hydrochloride and Atropine
作者: 于丽琴 ：武威市人民医院，甘肃 武威;
Abstract: Objective: To observe on treatment effect of severe AOPP combining penehyclidine hydrochloride (Changtuoning) and atropine. Methods: The clinical data of 180 patients with severe AOPP who were admitted to our hospital from January 2012 to October 2015 were analyzed retrospectively. Observation group used atropine and quickly achieved follow-up to maintain penehyclidine hy-drochloride in vivo anticholinergic drug concentration, while control group used penehyclidine hydrochloride. Two groups were supplemented with a series of rescue measures of chlorine and phosphorus fixed injection, quickly removing the poison, etc.; there were 90 cases in each group. The atropine time, the time of the ChE activity recovery reaching 70%, complication rate, hospita-lization expenses, cure rate, and some other indexes were analyzed. Results: In the observation group, the atropine time was (26.1 ± 14.7) min, the time of the ChE activity recovery reaching 70% was (4.0 ± 1.1) d, the complication rate was (1.11 (1)), the average hospitalization days were (5 ± 1.2) d, the cost of hospitalization was (6268 ± 238 yuan), and the cure rate was (100.00 (90)). In the control group, the atropine time was (43.7 ± 21.8) min, the time of the ChE activity recovery reach-ing 70% was (6.0 ± 2.3) d, the complication rate was (6.67 (6)), the average hospitalization days were (9 ± 1.5) d, the average hospitalization days were (7921 ± 230 yuan), and the cure rate was (96.67 (87)). The differences of the indicators between the observation group and the control group were statistically significant (P < 0.01). Conclusion: Using penehyclidine hydrochloride combined with atropine for treating severe AOPP critically costs shorter time; cholinesterase is not easy to aging; dosage is less; effect lasts longer; curative effect is remarkable; complication rate is low. It is proved that this treatment can significantly improve the success rate of treating AOPP patients, and is safe and reliable.
文章引用: 于丽琴 (2016) 长托宁与阿托品联用救治急危重症AOPP的疗效分析。 亚洲急诊医学病例研究， 4， 9-13. doi: 10.12677/ACREM.2016.42002
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