Fabrication of Galactosylated Alginate Nanoparticles as Drug Delivery System for Hepatocellular Carcinoma
Abstract: The alginate derivative naonoparticles modified by galactose (HA-Gal) with various galactose (Gal) substitution degrees were synthesized to evaluate their potential for hepatocellular carcinoma (HCC) targeting. Their physicochemical characteristics were investigated. Doxorubicin hydrochloride (DOX) as a model antitumor drug was incorporated into the HA-Gal. The in vitro drug release and antitumor capability of DOX loaded HA-Gal (DOX/HA-Gal) with different Gal substitution degrees were evaluated. Negatively charged DOX/HA-Gal appeared monodisperse and spherical in shape with a size range of 180 - 250 nm, and their Zeta potentials were above 30 mV (absolute value). The size, Zeta potentials, encapsulation efficiency and in vitro cytotoxicity of HA-Gal were increased with the increment in Gal substitution degree.
文章引用: 李政雄 , 吴晓盈 (2016) 半乳糖修饰的海藻酸纳米载体构建及其抗肿瘤功效。 纳米技术， 6， 23-32. doi: 10.12677/NAT.2016.62004
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