银促进的α-氨基芳乙酮与NH4PF6的缩合环化反应:2-芳甲酰基咪唑衍生物的合成研究
Silver-Promoted Cyclization of α-Aminoacetophenone with NH4PF6: Synthesis of 2-Arylformylimidazole Derivatives

作者: 王祚辉 , 程晓雪 , 王 浩 , 凌心茹 , 赵晨晨 , 胡茂林 :温州大学化学与材料工程学院,浙江 温州;

关键词: α-氨基芳乙酮咪唑缩合反应环化反应氧化脱胺α-Aminoacetophenone Imidazole Condensation Cyclization Oxidative Deamination

摘要:
本文发展了一种由六氟磷酸铵提供铵源,与两分子α-氨基芳乙酮在醋酸银的氧化作用下,经过缩合、脱胺、环化等串联反应合成2-芳甲酰基咪唑衍生物的新方法。在最优条件下,合成了8种2-芳甲酰基咪唑衍生物,收率为52%~93%。所有的产物结构通过IR、NMR和MS等手段表征。该方法具有原料简单易得、操作简便等优点。

Abstract: A new method for AgOAc-oxidative cyclization of α-aminoacetophenones with NH4PF6 leading to 2-arylformylimidazoles derivatives has been developed. Under the optimal reaction conditions, a wide range of 2-arylformylimidazoles derivatives were synthesized in moderate to good yields ranging from 52% to 93%. These products were confirmed by IR, NMR and MS. The results show that this method has advantages such as the availability for raw materials and simple chemical operations.

文章引用: 王祚辉 , 程晓雪 , 王 浩 , 凌心茹 , 赵晨晨 , 胡茂林 (2016) 银促进的α-氨基芳乙酮与NH4PF6的缩合环化反应:2-芳甲酰基咪唑衍生物的合成研究。 有机化学研究, 4, 6-12. doi: 10.12677/JOCR.2016.41002

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