NF-КBP65和BCL-2蛋白在多形性腺瘤中的表达
The Expression of NF-КBP65 and BCL-2 Protein in Pleomorphic Adenoma

作者: 陈昌晖 :宁波市北仑区人民医院口腔科,浙江 宁波; 肖维华 :南昌大学第二附属医院口腔颌面外科,江西 南昌;

关键词: 多形性腺瘤NF-КBP65BCL-2免疫组化Pleomorphic Adenoma NF-КBP65 BCL-2 Immunohistochemical

摘要:
目的:检测NF-КBP65与BCL-2蛋白在多形性腺瘤及瘤旁正常涎腺组织中的表达情况,探讨NF-КBP65与BCL-2蛋白在多形性腺瘤的表达意义。方法:采用免疫组织化学S-P法检测20例涎腺多形性腺瘤组织石蜡标本中NF-КBP65与BCL-2蛋白表达水平,以瘤旁正常涎腺组织作为对照,进行组内及组间比较。结果:多形性腺瘤和瘤旁正常涎腺组织中NF-КBP65表达的阳性率分别为55%和10.0%,差异有统计学意义(P<0.05);BCL-2表达的阳性率分别为35%和10.0%,差异有统计学意义(P<0.05)。结论: NF-КBP65 和BCL-2的协同作用可能对多形性腺瘤的发生、发展起重要作用。

Abstract: Objective: To detect the expression and discuss the expression meaning of NF-КBP65 and BCL-2 protein in pleomorphic adenoma. Methods: The expression of NF-КBP65 and BCL-2 protein in pa-raffin embedded specimens of pleomorphic adenoma and adjacent normal salivary gland tissue of 20 cases was detected using immunohistochemical S-P method. Results: The positive rates of NF-КBP65 expression in pleomorphic adenoma and adjacent normal salivary gland tissue were  55% and 10%, and the positive rates of BCL-2 expression were 35% and 10% respectively. The differences of NF-КBP65 and BCL-2 expression in pleomorphic adenoma and tumor adjacent normal salivary gland tissue were statistically significant (P < 0.05). Conclusion: NF-КBP65 and BCL-2 may play an important role in pleomorphic adenoma occurrence and development.

文章引用: 陈昌晖 , 肖维华 (2016) NF-КBP65和BCL-2蛋白在多形性腺瘤中的表达。 生物医学, 6, 1-5. doi: 10.12677/HJBM.2016.61001

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