结节性痒疹患者血清MAO,总IgE测定及其临床意义
Measurement of Serum IgE and Monoamine Oxidase in Prurigo Nodularis and Its Clinical Significance

作者: 黄建国 , 龚启英 :广州市花都区人民医院,南方医科大学附属花都医院皮肤科,广东 广州; 黄朝頔 :遵义医学院珠海校区临床医学系,广东 珠海; 李桂明 :重庆医科大学第一医院皮肤科,重庆;

关键词: 结节性痒疹单胺氧化酶IgEPrurigo Nodularis Monoamine Oxidase Immunoglobulin E

摘要:
目的:探讨IgE,单胺氧化酶(MAO)在结节性痒疹中的作用。方法:选择确诊的结节性痒疹患者90例及其90例正常人,分别采用直接化学发光法检测其血清总IgE,采用连续监测法测定单胺氧化酶并进行比较。结果:结节性痒疹患者血清总IgE含量高于健康对照组(P < 0.05),患者血清MAO含量高于健康对照组(P < 0.01)。结论:IgE,MAO参与了结节性痒疹的发病过程,为临床诊断及治疗提供了科学依据。

Abstract: Objective: To study the role of serum IgE and Monoamine oxidase (MAO) in Prurigo nodularis. Me- thods: 90 cases of Prurigo nodularis patients and 90 healthy controls were selected in the investigation. The total serum IgE were measured by Direct chemiluminescence method. The serum MAO were measured by Continuous monitoring method. Results: The levels of total serum IgE in Prurigo nodularis patients were significantly higher than those in healthy controls (P < 0.05). The levels of serum MAO in Prurigo nodularis patients were significantly higher than those in healthy controls (P < 0.01). Conclusion: Serum IgE, MAO may play a part of role in the pathogenesis of Prurigo nodularis, and the results provide the science views for clinical diagnosis and treatment.

文章引用: 黄建国 , 黄朝頔 , 龚启英 , 李桂明 (2015) 结节性痒疹患者血清MAO,总IgE测定及其临床意义。 医学美容, 3, 7-11. doi: 10.12677/HJMC.2015.32002

参考文献

[1] 赵辨. 中国临床皮肤病学[M]. 南京: 江苏科学技术出版社, 2009: 1293-1294.

[2] 黄建国, 李桂明. 5-羟色胺与精神相关性皮肤病[J]. 临床皮肤科杂志, 2002, 31(12): 380-381.

[3] Schneider, G., Hockmann, J. and Stumpf, A. (2014) Psychosomatic Aspects of Prurigo Nodularis. Hautarzt, 65, 704- 708.
http://dx.doi.org/10.1007/s00105-014-2758-7

[4] 黄建国, 龚启英, 李桂明. 人类皮肤中的5-羟色胺能系统[J]. 中国皮肤性病学杂志, 2005, 19(9): 564-566.

[5] 黄建国, 龚启英, 李桂明. 人类皮肤中5-羟色胺的免疫学作用机制[J]. 中国麻风皮肤病学杂志, 2006, 22(4): 312- 315.

[6] Bortolato, M., Godar, S.C., Alzghoul, L., Zhang, J., Darling, R.D., Simpson, K.L., Bini, V., Chen, K., Wellman, C.L., Lin, R.C. and Shih, J.C. (2012) Monoamine Oxidase A and A/B Knockout Mice Display Autistic-Like Features. International Journal of Neuropsychopharmacology, 31, 1-20.

[7] 陈剑峰, 王恩多. 单胺氧化酶[J]. 生物化学与生物物理进展, 2000, 27(5): 504-507.

[8] Sharma, A.D. (2013) Oral Ketotifen and Topical Antibiotic Therapy in the Management of Pruritus in Prurigo Nodularis: A Randomized, Controlled, Single-Blind, Parallel Study. Indian Journal of Dermatology, 58, 355-359.
http://dx.doi.org/10.4103/0019-5154.117300

[9] 范国娟. 结节性痒疹发病机制及治疗的部分研究进展[J]. 中国麻风皮肤病杂志, 2014, 30(2): 91-92.

[10] 董秀芹, 刘涛, 肖洁平, 李智珍, 王红燕, 方俊华, 梁倩文, 黄新霞. 结节性痒疹的特异性免疫治疗的研究[J]. 中国美容医学, 2012, 21(12): 118-119.

[11] Tanaka, M., Aiba, S., Matsumura, N., Aoyama, H. and Tagami, H. (1995) Prurigo Nodularis Consists of Two Distinct Forms: Early-Onset Atopic and Late-Onset Non-Atopic. Dermatology, 190, 269-276.
http://dx.doi.org/10.1159/000246715

[12] Böhme, T., Heitkemper, T., Mettang, T., Phan, N.Q. and Ständer, S. (2014) Clinical Features and Prurigo Nodularis in Nephrogenic Pruritus. Hautarzt, 65, 714-720.
http://dx.doi.org/10.1007/s00105-014-2756-9

分享
Top