The Diagnostic and Therapeutic Application of Circulating microRNAs in Breast Cancer
Abstract: MicroRNAs (miRNAs) are a class of short non-coding regulatory RNAs with an etiological contribution to carcinogensis. The involvement of miRNAs in breast cancer has been reiterated and irrefutably proved by many studies. Circulating miRNAs refer to the cell free miRNAs in the blood or other body fluids, with characteristics such as remarkable stability, ease of access, minimal invasiveness, possibility of repeated sampling, and proven roles in cancer development and progression, so it has been regarded as one of the most potential biomarkers of tumor. This review focuses on recent-finding of circulating miRNAs as biomarkers in early diagnostic, prognostic indications and treatment selection, along with an appraisal of the translational implication of this field. We also addressed the future and the problems and challenges that need to be overcome to achieve clinical implementation of circulating miRNAs.
文章引用: 薛丽 , 白玉杰 (2015) 循环microRNAs在乳腺癌诊治中的应用。 医学诊断， 5， 47-53. doi: 10.12677/MD.2015.53010
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