New Method for the Synthesis of 4-Thiothymidine
Abstract: 4-Thiothymidine combined with UVA (light shading effect with long-wave ultraviolet) as a potentially novel therapy for cancer provides a new way, UVA-sensitive 4-thiothymidine was obtained through the study of the modification of thiothymidine at 4-position, and reached the role of treatment of tumor cells under the synergy of UVA. In order to obtain 4-Thiothymidine drugs with new optical properties, triazole and P2S5 are used in previously reported methods. In this study, Lawesson reagent was adopted to prepare 4-thiothymidine. Under the optimized conditions, the reaction time was significantly reduced and the yield increased. The structure of the product was characterized by 1H-NMR and 13C-NMR.
文章引用: 闫德峰 , 赫玲爽 , 马克东 , 张晓辉 , 李德鹏 (2015) 4-硫胸苷的合成新方法。 合成化学研究， 3， 70-73. doi: 10.12677/SSC.2015.33011
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