Determination of Residual Solvent in Clofedanol by Gas Chromatography with Headspace Sampling
Abstract: Objective: To establish a GC method for the determination of residual solvent in clofedanol. Methods: DB-624 chromatographic column (coated with 6% cyanopropylphenyl-94% dimethylpolysiloxane, length 30 m, I.D. 0.53 mm, film 3.0 μm) was adopted. The column temperature was programmed, kept at 40˚C for 3 min, and then increased by 20˚C/min to 240˚C for 3 min. The temperature of FID detector was 250˚C and the temperature of inlet was 200˚C. The carrier gas was He at a flow rate of 5 mL/min. The injection volume was 1 mL. Results: The calibration curves of five solvents all showed good linearity in a detected concentration range (r > 0.9990); the range of average recovery was between 96.0% and 103.0%. Conclusion: The method was accurate, reliable and sensitive, and can be used for assay of residual organic solvent in clofedanol.
文章引用: 王 琳 , 丁海宏 , 张智红 , 胡 丽 (2015) 顶空气相色谱法测定氯苯达诺原料药中的残留溶剂含量。 药物资讯， 4， 31-34. doi: 10.12677/PI.2015.43004
 陈晶晶 (2012) 几种原料药中有机溶剂残留量的测定方法研究. 硕士论文, 湖北中医药大学, 武汉.
 刘冬 (2007) 顶空气相色谱法用于药物中残留溶剂检测的研究. 硕士论文, 北京中医药大学, 北京.