神经系统表观遗传进展
Epigenetics Advances in the Nervous System

作者: 王 卓 * , 戴甲培 :中南民族大学武汉神经科学和神经工程研究所,中南民族大学生命科学学院; 覃 瑞 , 余光辉 :中南民族大学生命科学学院,南方少数民族地区资源保护综合利用联合工程中心,武陵山区特色资源植物种质保护与利用湖北省重点实验室;

关键词: 表观遗传神经系统神经系统功能与疾病跨代遗传Epigenetics Central Nervous System CNS Functions and Disorders Transgenerational Inherience

摘要:
神经表观遗传学是一门新兴的学科,主要研究中枢神经系统的表观遗传机制。最新研究发现,获得性行为、中枢神经系统功能紊乱、神经可塑性、神经毒性和药物成瘾以及神经系统疾病的发生等现象都涉及到相关的表观遗传机制。人类神经系统发育和功能也与表观遗传机制有关,并且表现出跨代遗传的表观遗传效应。本文综述了神经表观遗传学研究方面的进展和相应的机制。

Abstract: Neuroepigenetics is a new emerging field, mainly focusing on epigenetic mechanism study of the central nervous system (CNS). New discoveries show that the CNS-related behaviors, CNS disorders, neural plasticity, neurotoxicity, drug addiction and other neurological disorders are related to the underlying epigenetic mechanisms. Moreover, the development and the function of the human nervous system are also linked with epigenetic mechanisms, exhibiting transgenerational epigenetic effects. Advances in the study of epigenetic mechanisms in CNS are reviewed in this contribution.

文章引用: 王 卓 , 覃 瑞 , 戴甲培 , 余光辉 (2015) 神经系统表观遗传进展。 千人·生物, 2, 1-9. doi: 10.12677/QRB.2015.21001

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