Pluronic F127 Regulated Coprecipitation Preparation and Characterization of MnFe2O4 Nanoparticles
Abstract: MnFe2O4 nanoparticles have great potentials in Magnetic Resonance Imaging and tumor hyper-thermia. However for biomedical applications, the main challenges would be of great difficulty to synthesize MnFe2O4 nanoparticles with homogeneous size and morphology, high magnetization, and good biocompatibility. Pluronic F127 was utilized to regulate the coprecipitation process of MnFe2O4 nanoparticles. Objective: The regulation of Pluronic F127 in the coprecipitation process was expected to facilitate the formation of MnFe2O4 nanoparticles with uniform size and morphology, higher magnetization, and low cytotoxicity. Methods: MnFe2O4 nanoparticles were prepared by chemical coprecipitation method in presence of Pluronic F127. X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM) were used to characterize the composition, microstructure, morphology, and magnetization of the prepared MnFe2O4 nanoparticles. And MTT assays were conducted to investigate their cytotoxicity. Results: The ferromagnetic MnFe2O4 nanoparticles (F127-NPs) were successfully synthesized in the presence of Pluronic F127 via coprecipitation method. Compared to the nanoparticles prepared without Pluronic F127, F127-NPs exhibited a more uniform size of ca. 50 nm and a sphere-like shape. Moreover, F127-NPs possessed a higher magnetization (44.8 emu/g) and exhibited little inhibition to HUVE cells. Conclusion: Pluronic F127 could regulate the coprecipitation process to form the high quality MnFe2O4 nanoparticles and improve the cytocompatibility of nanoparticles. And this method is of a great potential to be applied in the field of biomedicine.
文章引用: 胡 杨 , 尹光福 , 蒲曦鸣 (2015) 普朗尼克F127调控下MnFe2O4纳米粒子的共沉淀制备及其性能表征。 材料科学， 5， 119-125. doi: 10.12677/MS.2015.53017
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