A Hypothesis: TGF-β1/Smad3 Signaling Pathway Participates in the Development of Parkinson’s Disease
作者: 于永鹏 ：潍坊医学院附属文登中心医院神经内科，山东 威海;
Abstract: Parkinson’s disease (PD), which is one of neurodegenerative diseases, is a serious threat to human health. So far there has been no special treatment for it. PD onset is closely associated with the disorders of iron metabolism and its inducing and mediating oxidative stress response in the brain. The mechanism of its regulation is still elusive. Recently it was found that transforming growth factor-β1 (TGF-β1) can down-regulate the expression of ferritin heavy chain (FHC) and lead to cell labile iron increasing. It was found that TGF-β1/Smads signaling pathway could regulate cellular iron transport and metabolic balance by regulating hepcidin (Hep) expression in the hemochromatosis research. This review focused on the possible mechanism of TGF-β1/Smads signaling pathway involving iron metabolism and oxidative stress regulation and proposed a medical hypothesis: TGF-β1/Smad3 signaling pathway might participate in the process of PD de-velopment. It is expected that the experiment will be performed to explore the effect of abnormal regulation of this signaling pathway on the iron metabolism protein expressions and iron levels in PD, and to investigate regulatory mechanism of the TGF-β1 signaling on oxidative stress in dopa-minergic neurons. It will be of great significance to reveal the mechanism of PD, and to find effective treatments for it.
文章引用: 于永鹏 (2015) 假说：TGF-β1/Smad3信号通路参与帕金森病的发生发展。 自然科学， 3， 19-25. doi: 10.12677/OJNS.2015.32004
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