鹅去氧胆酸的氧化产物合成
The Synthesis of the Oxidation of Chenodeoxycholic Acid

作者: 蔡烈峰 :杭州和泽医药科技有限公司;

关键词: 鹅去氧胆酸氧化合成Chenodeoxycholic Acid Oxidation Synthesis

摘要:
目的:选择性氧化得到鹅去氧胆酸不同位置的氧化产物。方法:使用碳酸银作氧化剂得到3位羟基被氧化的产物;使用N-溴代丁二酰二胺作氧化剂得到7位羟基被氧化产物;使用琼斯试剂作氧化剂得到3位和7位羟基均被氧化的产物。结果:本工艺提供的选择性氧化方法成本更低,收率更高,后处理更方便,适合工业化生产。结论:本文所选择的方法具有条件温和,操作简单,成本低,收率高,适合工业化大生产的优点。

Abstract: Objective: Regioselective oxidation of chenodeoxycholic acid in different positions. Methods: The third was oxidized with silver carbonate; the seventh was oxidized with N-bromosuccinimide; the third and the seventh were oxidized with Jones reagent. Results: The synethesis of regioselective oxidation of chenodeoxycholic acid has advantages such as lower cost, higher yield, easier in aftertreatment and more suitable for industrialized production. Conclusion: This synthetic process has advantages such as mild conditions, easy operation, low cost and high yield, and is suitable for large-scale production.

文章引用: 蔡烈峰 (2015) 鹅去氧胆酸的氧化产物合成。 药物化学, 3, 11-14. doi: 10.12677/HJMCe.2015.32002

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