Protective Effects of Qing-Gan-Li-Shui Formula on Intraocular Pressure and Retinal Ganglion Cells of Glaucoma Rats
Abstract: Objectives: Glaucoma ranks second among those that induce vision loss. Qing-Gan-Li-Shui Formula is derived from Jusheng Zou, an experienced TCM doctor, and exhibited effective for glaucoma. This project is focusing on related basic research on glaucoma rats’ intraocular pressure (IOP) and retinal ganglion cells (RCGs). Methods: Modeling by occluding episcleral veins. Groups are treated with Qing-Gan-Li-Shui Formula and Timolol Maleate drops, respectively and concurrently. Model group and sham-model group were established as control. We monitored IOP regularly, collected and stained retina with H&E dye to observe RCGs. Results: Model of high IOP was established suc-cessfully. IOP of Chi-Western Group (9.45 ± 1.04) is better than individual significantly (Chinese Medical Group: 10.50 ± 1.98; Western Medical Group: 10.91 ± 1.76). RCGs of Chi-Western Group (53.00 ± 12.33) are more than Chinese Medical Group’s (47.80 ± 9.60) and Western Medical Group’s (38.00 ± 12.30) significantly. Conclusions: Qing-Gan-Li-Shui Formula exhibited protective effects on glaucoma with reduction on IOP and inhibition on RGCs apoptosis.
文章引用: 王蕾蕾 , 张殷建 (2015) 观察清肝利水方对高眼压大鼠眼压及视网膜神经节细胞保护作用。 中医学， 4， 5-12. doi: 10.12677/TCM.2015.42002
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