The Changes of Amplitude of Low-Frequency Fluctuation in the Acute Phase Patients with Concussion
Abstract: Objective: To investigate the change of amplitude of low-frequency fluctuation (ALFF) in acute phase patients with concussion. Methods: 10 patients with concussion and 10 healthy control subjects were performed at GE MR750 3T by using the methods of blood oxygenation level de-pendent-functional magnetic resonance imaging (BOLD fMRI) and ALFF in this study. Results: Compared with the control subjects, the patients with concussion showed significantly increased ALFF values in limbic lobe, cingulate gyrus, precuneus, left superior temporal gyrus, left middle temporal gyrus and right frontal gyrus. The clinical manifestations of these patients were the changes of cognitive function such as memory, language and emotional responses. Conclusion: The changes of cognitive function on the patients with concussion were associated with the increased ALFF values in the cognitive-related brain areas.
文章引用: 王卫民 , 郝泽林 , 程 军 , 吴建跃 , 裘五四 , 姜启周 , 肖国民 , 臧玉峰 , 丁建平 (2015) 脑震荡急性期患者功能磁共振低频振幅变化意义初探。 亚洲急诊医学病例研究， 3， 7-12. doi: 10.12677/ACREM.2015.32002
 Yang, H., Long, X.Y., Yang, Y., Yan, H., Zhu, C.Z., Zhou, X.P., Zang, Y.F. and Gong, Q.Y. (2007) Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. Neuroimage, 36, 144-152.
 Zang, Y.F., He, Y., Zhu, C.Z., Cao, Q.J., Sui, M.Q., Liang, M., Tian, L.X., Jiang, T.Z. and Wang, Y.F. (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain and Development, 29, 83-91.
 Zhang, Z., Lu, G., Zhong, Y., Tan, Q., Chen, H., Liao, W., Tian, L., Li, Z., Shi, J. and Liu, Y. (2010) fMRI study of mesial temporal lobe epilepsy using amplitude of low-frequency fluctuation analysis. Human Brain Mapping, 31, 1851-1861.
 Zhou, Y., Shu, N., Liu, Y., Song, M., Hao, Y., Liu, H., Yu, C., Liu, Z. and Jiang, T. (2008) Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophernia. Schizophrenia Research, 100, 120- 132.
 Wu, Q.Z., Li, D.M., Kuang, W.H., Zhang, T.J., Lui, S., Huang, X.Q., Chan, R.C., Kemp, G.J. and Gong, Q.Y. (2011) Abnormal regional spontaneous neural activity in treatment-refractory depression revealed by resting-state fMRI. Human Brain Mapping, 32, 1290-1299.
 Wu, T., Long, X., Zang, Y., Wang, L., Hallett, M., Li, K. and Chan, P. (2009) Regional homogeneity changes in patients with Parkinson’s disease. Human Brain Mapping, 30, 1502-1510.
 Zou, Q.H., Zhu, C.Z., Yang, Y., Zuo, X.N., Long, X.Y., Cao, Q.J., Wang, Y.F. and Zang, Y.F. (2008) An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF. Journal of Neuroscience Methods, 172, 137-141.
 Xuan, Y., Meng, C., Yang, Y., Zhu, C., Wang, L., Yan, Q., Lin, C. and Yu, C. (2012) Resting-state brain activity in adult males who stutter. PLoS One, 7, e30570.
 Bai, F., Liao, W., Watson, D.R., Shi, Y., Yuan, Y., Cohen, A.D., Xie, C., Wang, Y., Yue, C., Teng, Y., Wu, D., Jia, J. and Zhang, Z. (2011) Mapping the altered patterns of cerebellar resting-state function in longitudinal amnestic mild cognitive impairment patients. Journal of Alzheimer’s Disease, 23, 87-99.
 Zhou, B., Chen, Q., Zhang, Q., Chen, L., Gong, Q., Shang, H., Tang, H. and Zhou, D. (2010) Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: A resting-state functional magnetic resonance imaging study. Movement Disorders, 25, 1226-1231.
 Yin, Y., Li, L., Jin, C., Hu, X., Duan, L., Eyler, L.T., Gong, Q., Song, M., Jiang, T., Liao, M., Zhang, Y. and Li, W. (2011) Abnormal baseline brain activity in posttraumatic stress disorder: A resting-state functional magnetic resonance imaging study. Neuroscience Letters, 498, 185-189.
 Johnson, B., Zhang, K., Gay, M., Horovitz, S., Hallett, M., Sebastianelli, W. and Slobounov, S. (2012) Alteration of brain default network in subacute phase of injury in concussed individuals: Resting-state fMRI study. NeuroImage, 59, 511-518.
 Zhou, Y., Milham, M.P., Lui, Y.W., Miles, L., Reaume, J., Sodickson, D.K., Grossman, R.I. and Ge, Y. (2012) Default-mode network disruption in mild traumatic brain injury. Radiology, 265, 882-892.