Current Progress of Structural Studies on β2 Adrenergic Receptor
Abstract: Beta-2 adrenergic receptor is an important member among G protein-coupled receptors superfa-mily. As a membrane protein, it is difficult to crystalize and its three-dimensional structure is not known until recent years. Thanks to the development of the crystal engineering techniques and the breakthroughs in the free electron X-ray laser crystallography, many crystal structures of β2 adrenergic receptor at different states become available now. The discovery of the crystal structure β2 adrenergic receptor has enriched our understanding on many life phenomena and its impact to the structure-based drug design cannot be overestimated. We review the discovery history of β2 adrenergic receptor crystal structures, the structural characteristics of the receptor, the in-teractions between the receptor and different subtypes of the ligands (agonist, inverse agonist and antagonist) and clinical applications.
文章引用: 唐令利 , 张 鹏 , 王先龙 (2015) β2肾上腺素受体结构研究进展。 药物化学， 3， 1-10. doi: 10.12677/HJMCe.2015.31001
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