The Physiological Functions of Aquaporins

作者: 耿晓强 , 杨宝学 :北京大学基础医学院药理学系,北京;

关键词: AQP膜整合蛋白水通道水转运Aquaporin Integral Transmembrane Protein Water Channel Water Transport


Abstract: The aquaporins (AQPs) are a family of 13 small hydrophobic integral transmembrane water channel proteins involved in transcellular and transepithelial water movement and fluid transport. The study of aquaporins has experienced from discovery to the exploration of their physiological functions. It has been found that aquaporins are expressed in various tissues and organs and they have different physiological functions, including urine concentration, exocrine gland secretion, hydration of brain, transduction of neuronal signaling and metabolism. The studies on aquaporins can provide novel ideas to the mechanism and therapy of related diseases. This review article dis-cusses the recent researches on the physiological functions of AQPs in different tissues and organs.

文章引用: 耿晓强 , 杨宝学 (2014) 水通道蛋白生理学功能的研究进展。 生理学研究, 2, 19-32. doi: 10.12677/JPS.2014.24004


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