The Study on the Synthesis of PGs Ke Intermediate—Corey Lactone
Abstract: Corey lactone is the key intermediate of synthetizing the prostaglandin analogues. In this paper, we use the norbornadiene as the raw material to synthetize the Corey lactone. Through Prins reaction, Baeyer-Villiger oxidation, splitting the chiral intermediate and a series of reaction successfully, the structure has been confirmed by the LC-MS and the NMR. The reagent and the solvent which are used in this method are so common and inexpensive that they can be suitable for industrialized production.
文章引用: 邓 涛 , 毛 伟 , 陶 春 , 李勤耕 (2015) 前列腺素类药物关键中间体Corey Lactone的合成工艺研究。 药物资讯， 4， 15-21. doi: 10.12677/PI.2015.41002
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