The Preparation of 2-Fluorine Propionic Acid by Ultrasound Method
Abstract: In many drugs, fluorochemicals have a strong physiological activity. α-fluorine propionic acid is a small chiral organic molecule; since it has an asymmetric carbon, it has an important significance in application of organic synthesis and some drugs’ structural modification. In this paper, the syn-thesis of 2-fluorine propionic acid was studied, using fluorinated diazotization method and halogen fluorination method. It is a classic method of diazotization for fluorination. However, the reaction transformation rate is low when the method is applied to the synthesis of 2-fluorine propionic acid, which is only 14% in literatures. And the reaction transformation rate may be greatly improved by using fluoride (such as potassium fluoride) under ultrasonic condition compared with fluorinated diazotization method.
文章引用: 舒 浪 , 田崎峰 , 邵开元 , 刘 明 , 胡文祥 (2014) 超声波法制备2-氟丙酸。 有机化学研究， 2， 43-46. doi: 10.12677/JOCR.2014.24007
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