Clinical Observation of High Intensity Focused Ultrasound (HIFU) Ablation Combined with Qingyihuaji Formula for Salvage
Treatment for Advanced Pancreatic Cancer Patients Failed to Systemic Chemotherapy
Abstract: Objective: To evaluate the efficacy and toxicity of high intensity focused ultrasound (HIFU) for local ablation of pancreatic tumor combined with Qingyihuaji formula as the palliative treatment for advanced pancreatic cancer patients failed to systemic chemotherapy. Methods: 29 advanced pancreatic cancer patients who failed systemic chemotherapy accepted HIFU and Qingyihuaji formula treatment from January 2012 to December 2013. The occurrence of liver, retroperitoneal, and other parts of the metastasis in 23 cases, 6 cases of local advanced. The curative effects, the pain changes and toxicity were evaluated, and progression-free survival (PSF) and over survival (OS) were calculated from the date of follow-up. Results: All the 29 patients can receive the short-term efficacy evaluation. There were 3 cases of partial response (PR), 7 of stable disease (SD) and 19 of progressive disease (PR) with RR of 10.3% and DCR of 34.5%. The median PFS and OS were 2.5 and 8.1 months, respectively. 75% patients reported significant reductions in their pain levels. The KPS was 78.5 6.4 after combination treatment, higher than 64.5 4.2 before treatment. The major side effect was grade 1 - 2 gastrointestinal response. There were no marrow toxicities and serious complications such as gastrointestinal hemorrhage or perforation of gastrointestinal tract. Conclusion: HIFU for local ablation of pancreatic tumor combined with traditional Chinese medicine in the treatment of failure of chemotherapy in advanced pancreatic cancer is safe, effective, and light toxicity, worthy of further clinical study.
文章引用: 何胜利 , 沈 婕 , 胡南华 , 蔡芸芸 , 孙贤俊 , 刘鲁明 (2015) 清胰化积方联合高强聚焦超声消融治疗化疗失败晚期胰腺癌的临床疗效观察。 亚洲肿瘤科病例研究， 4， 1-7. doi: 10.12677/ACRPO.2015.41001
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