多种化学因素对前列腺细胞连接蛋白Cx43的影响及对前列腺肿瘤治疗意义的研究进展
The Effects of Various Chemical Factors on Prostate Tumor Cells of Cx43 and the Significance of the Cancer Treatment

作者: 胡 君 :南京医科大学江宁校区,南京; 王 婷 :南京医科大学基础医学院,细胞生物学系,南京;

关键词: 细胞连接蛋白43前列腺肿瘤化学因素Connexon 43 Prostate Cancer Chemical Factors

摘要:
前列腺肿瘤(prostate cancer, PCa)作为常见的老年男性肿瘤疾病,发病率正在逐年上升,细胞连接蛋白(Connexon, Cx)的表达异常是其发生机制之一。研究表明前列腺肿瘤细胞较前列腺上皮表达Cx43明显降低,存在细胞间隙连接通讯(GJIC)缺陷,故Cx43表达缺陷可能在前列腺肿瘤发生发展过程中发挥一定作用。研究发现茶多酚类物质,含硒类物质、激素类物质、维生素类、生物碱类等多种化学物质都对前列腺肿瘤细胞Cx43的表达有影响,进而影响前列腺肿瘤发展状况,故本文将对多种化学因素对前列腺肿瘤细胞连接蛋白Cx43的影响及治疗意义作一综述。

Abstract: Prostate cancer is a common cancer disease within older male populations and its incidence rate increased year by year. The abnormal exception of connexon is one of its pathogenesis. Researches show that Cx43 expression in prostate cancer was effectively lower compared with prostate epi-thelial, what’s more, there existed a gap junctional intercellular communication defects in prostate cancer. So, Cx43 expression defects may significantly affect the prostate cancer process. Researches also show that tea polyphenols substances, selenium substances, hormone-like substances, vitamins, alkaloids, and other chemical substances are also have different levels of effects on the expression of Cx43 in prostate tumor cells. Therefore, they also influenced the development of prostate cancer. So, the following article will mainly state the effecting of variety chemical factors on Cx43 in prostate cancer cells and therapeutic implications.

文章引用: 胡 君 , 王 婷 (2015) 多种化学因素对前列腺细胞连接蛋白Cx43的影响及对前列腺肿瘤治疗意义的研究进展。 世界肿瘤研究, 5, 8-14. doi: 10.12677/WJCR.2015.51002

参考文献

[1] 樊智敏, 刘耀等 (2011) Cx43介导的GJIC功能在白血病的研究进展. 国际检验医学杂志, 32, 1170-1172, 1175.

[2] 王杰, 戴佳琳, 胡旭初等 (2013) 人类Cx43基因的生物信息学分析及其法医学研究意义. 中国卫生检验杂志, 3, 667-669.

[3] Ai, X. and Pogwizd, S.M. (2005) Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circulation Research, 96, 54-63.

[4] 王琪 (2010) 缝隙连接蛋白43研究进展. 中西医结合研究, 2, 312-316.

[5] Shl, G. and Willecke, K. (2004) Gap junction and connexin family. Cardiovascular Research, 62, 228-232.

[6] Zipin-Roitman, A., Meshel, T., Sagi-Assif, O., et al. (2007) CXCL10 promotes invasion-related properties in human colorrctal carcinoma cells. Cancer Research, 67, 3396-3405.

[7] 郑久鸣, 曲宏伟, 姚锦梅等 (2013) 前列腺癌组织中Cx43和Survivin的表达及相关性研究. 现代泌尿外科杂志, 18, 381-383.

[8] 郑久鸣, 李晓强, 芦占元等 (2012) 间隙连接蛋白43在前列腺癌不同预后分组中的表达和临床意义. 现代泌尿外科杂志, 17, 578-580.

[9] Lamiche, C., Clarhaut, J., Strale, P., et al. (2012) The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells. Clinical and Experimental Metastasis, 29, 111-122.

[10] 虞桂芳 (2010) Cx43在前列腺癌组织和PC-3细胞株中的表达及其意义. 咸宁学院学报(医学版), 24, 290-292.

[11] Petrai, I., Rombouts, K., Lasagni, L., Annunziato, F., Cosmi, L., Romanelli, R.G., et al. (2008) Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. International Journal of Biochemistry & Cell Biology, 40, 1764-1774.

[12] 胡利平, 刘振湘, 白志明, 谈顺 (2014) 间隙连接蛋白家族中Cx26、Cx32、Cx43在前列腺癌组织中的表达. 中华男科学杂志, 1, 23-29.

[13] Jiang, Z., Xu, Y. and Cai, S. (2010) CXCL10 expression and prognostic significance in stage Ⅱ and Ⅲ colorectal cancer. Molecular Biology Reports, 37, 3029-3036.

[14] 王婧, 高玉堂 (2011) 茶多酚抗癌的流行病学研究进展. 肿瘤, 6, 553-557.

[15] 梁鑫 (2013) 不同浓度茶多酚对两种前列腺癌细胞系生长的影响及作用机制的研究. 青岛大学, 青岛.

[16] Adhami, V.M., Siddiquii, A., Sarfaraz, S., Khwaja, S.I., Hafeez, B.B., Ahmad, N. and Mukhtar, H. (2009) Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease. Clinical Cancer Research, 15, 1947-1953.

[17] Suganuma, M., Saha, A. and Fujiki, H. (2011) New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Science, 102, 317-323.

[18] 曹正国, 田超, 蒋茂林, 吴奎, 钟晓键, 黎建欣等 (2011) EGCG对人前列腺癌裸鼠移植瘤生长和间隙连接蛋白43表达的影响. 中国医师杂志, 10, 1301-1304.

[19] Rams, A., Matsushita, T., Charolidi, N., Rothery, S., Dupont, E. and Severs, N.J. (2006) Up-regulation of connexin43 correlates with increased synthetic activity and enhanced contractile differentiation in TGF beta-treated human aortic smooth muscle cells. European Journal of Cell Biology, 85, 375-386.

[20] 李鹤, 刘浩 (2010) 硒在前列腺癌和结直肠癌防治中的作用. 国外医学(医学地理分册), 1, 52-54.

[21] 钟明珠, 尧凯, 董培, 郭胜杰, 周芳坚, 韩辉 (2012) 硒-甲基硒代半胱氨酸通过缝隙连接蛋白43抑制前列腺癌DU145细胞生长的研究. 中华实验外科杂志, 12, 2364-2366.

[22] 刘艳波, 孙媛媛, 徐杰, 焦桥, 费聪聪, 赵晓晖等 (2014) 甲基硒酸对前列腺癌Lncap细胞的促凋亡作用. 中国男科学杂志, 1, 13-17.

[23] 师长进, 曾慧慧, 李鸿伟, 杨风光, 武学清, 俞莉章 (2003) 一种新型含硒化合物诱导PC-3前列腺癌细胞凋亡及其体内抑瘤作用的研究. 中华医学杂志, 22, 1984-1988.

[24] 杨鑫磊, 宿星, 刘文, 李晶, 巩平 (2012) 沙利度胺在肿瘤治疗中的应用及进展. 中国现代医药杂志, 1, 123-125.

[25] 李晓东 (2011) 沙利度胺对前列腺癌PC3细胞侵袭能力和细胞缝隙连接通讯的影响. 福建医科大学, 福州.

[26] 刘群, 乔颜春, 崔晶, 孙青 (2010) 大肠癌细胞与血管内皮细胞间缝隙连接通讯及Cx43蛋白表达的研究. 中华肿瘤防治杂志, 14, 1066-1069.

[27] 薛学义, 李晓东, 许宁, 郑清水, 魏勇, 江涛等 (2012) 沙利度胺对前列腺癌PC-3细胞的增殖及细胞缝隙连接通讯的影响. 中国肿瘤临床, 23, 1881-1885.

[28] 徐芳, 邹朝春 (2013) 先天性甲状腺功能减低仔鼠心肌细胞缝隙连接蛋白43和45的表达变化. 浙江医学, 17, 1547-1550.

[29] Hejmej, A., Górowska, E., Kotula-Balak, M., Chojnacka, K., Zarzycka, M., Zając, J. and Bilińska, B. (2013) Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate. BioMed Research International, 2013, Article ID: 407678.

[30] 孙馥箐, 段华 (2013) 雌激素对间隙连接蛋白43表达调控机制的研究进展. 妇产与遗传(电子版), 3, 40-43.

[31] 王建伟, 周利群, 纪世祺, 宋刚, 李学松, 何志嵩 (2011) 雌激素治疗激素难治性前列腺癌的疗效观察. 中华医学杂志, 32, 2247-2249.

[32] 徐娅蓓, 陈国强 (2005) 间隙连接蛋白43的表达调控及其功能. 国际病理科学与临床杂志, 6, 477-480.

[33] 袁磊 (2011) “抗炎-抗癌”: 维生素D抗肿瘤新机制. 中华医学教育探索杂志, 8, 1017-1019.

[34] Guo, Y.J., Shi, Z.M., Liu, J.D., et al. (2012) Meta-analysis of the relation between the VDR gene Taql polymorphism and genetic susceptibility to prostatecancer in Asian populations. Asian Pacific Journal of Cancer Prevention, 9, 4441.

[35] Giangreco, A.A., Vaishnav, A., Wagner, D., Finelli, A., Fleshner, N., Van der Kwast, T., et al. (2013) Tumor suppressor microRNAs, miR-100 and-125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue. Cancer Prevention Research, 6, 483-494.

[36] 王哲, 宋树森, 张晓明 (2013) 维生素D受体与肿瘤生长调节. 大家健康(中旬版), 10, 221-222.

[37] Culver, K.W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E.H. and Blaese, R.M. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumor. Science (Washington DC), 256, 1550-1552.

[38] Mesnil, M. and Yamasaki, H. (2000) Bystander effect in herpes simplex virus-thymidine ki-nase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication. Cancer Research, 60, 3989-3999.

[39] 陈卫国, 严春寅, 侯建全, 温端改, 浦金贤, 王恒兵 (2008) 全反式维甲酸提高激素非依赖性前列腺癌自杀基因治疗的旁观者效应. 中华男科学杂志, 2, 122-125.

[40] 辛丽丽, 张旭, 龚婕宁 (2013) 芹菜素抗癌机制研究进展. 中国实验方剂学杂志, 21, 335-341.

[41] 邢毅飞, 鲁功成, 肖亚军, 曾甫清, 张齐钧, 熊平, 冯玮 (2002) 单纯疱疹胸苷激酶/更昔洛韦系统杀伤前列腺癌细胞的“旁观者效应”及其调控. 中华医学杂志, 21, 1484-1487.

[42] 李卫林 (2014) 芹菜素抗肿瘤作用及机制研究进展. 中国医药导报, 21, 165-168.

[43] Musialik, E., Ryszawy, D., Madeja, Z. and Korohoda, W. (2013) Morpho-physiological heterogeneity of cells within two rat prostate carcinoma cell lines AT-2 and MAT-LyLu differing in the degree of malignancy observed by cell cloning and the effects of caffeine, theophylline and papaverine upon a proportion of the clones. Oncology Reports, 29, 1789-1796.

[44] 刘欣, 戴晓冬, 邓国英等 (2014) 紫杉醇抑制前列腺癌增殖的体内实验研究. 中国微生态学杂志, 10, 1155-1157.

[45] 丰晓威, 唐旭东 (2014) 植物生物碱的抗肿瘤机制. 国际肿瘤学杂志, 4, 254-258.

分享
Top