Clinical Curative Effect Observation of the Treatment of Metastatic Breast Cancer (MBC) with Capecitabine Medicine or Combination Chemotherapy
Abstract: Objective: To observe the clinical curative effect, toxic and side effect after the treatment of anth-racene ring and Paclitaxel chemotherapy with capecitabine for the recurrence metastasis of breast cancer. Method: From July 2007 to June 2014, Guizhou tumor hospital’s breast and gynecological oncology section received and treated 20 patients with metastatic breast cancer, among which, there were 4 cases with neck and supraclavicular lymph node metastasis, 5 cases with pulmonary metastasis, 4 cases with bone metastases, 1 case with liver metastasis, 1 case with brain metastases, 1 case with skin metastasis, 1 case with contralateral breast transfer and 3 cases with systemic multiple transfer. All patients underwent anthracycline or/and taxane adjuvant chemotherapy. They were given capecitabine medicine or combination chemotherapy. The median KPS score before the treatment in full cases was 90. there were 2 cases with capecitabine medicine; 2 cases with Capecitabine combined with Trastuzumab; 1 case with Capecitabine combined with bevacizumab; 9 cases with Capecitabine combined with gemcitabine; 1 case with Capecitabine combined with cis-platinum; 2 cases with Capecitabine combined with TAX (taxol); 3 cases with Capecitabine combined with docetaxel; 2 - 6 cycles of chemotherapy, the median cycles: 4. For all patients, the objective evaluation criteria in solid tumors (RECIST version 1.0) was used to evaluate the curative effect, and adverse reaction was evaluated by the toxicity of anticancer drug WHO standard evaluation. Result: There was 1 case lost to evaluate because of failure to follow-up. There were 19 cases evaluable, among which, 1 case reached CR; 6 cases reached PR; 6 cases reached SD; 6 cases reached PD, the effective rate of 36.8% (7/19). Transfer time is 2 - 33 months after treatment. The progression-free survival is 13 months. In 20 cases, 1 case had 4 degrees of bone marrow inhibition, 1 case had level 3 vomit gastrointestinal reaction, and they got better after symptomatic treatment; the remaining patients with 1 - 2 levels of digestive tract reaction could tolerate. There were 4 cases with 1 - 2 levels of extremities syndrome. Conclusion: The capecitabine multidrug therapy has certain curative effect on the metastatic breast cancer with failure of anthracene ring and Paclitaxel chemotherapy and the adverse reactions can be tolerated, so it is an effective treatment scheme.
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