维生素D在自闭症中作用的研究进展
Role of Vitamin D in Autism

作者: 贾飞勇 , 单 玲 , 冯俊燕 , 王 冰 , 李洪华 , 杜 琳 :吉林大学,第一医院小儿神经康复科,长春;

关键词: 自闭症维生素D免疫调节氧化应激基因稳定Autism Vitamin D Immunologic Regulation Oxidative Stress Genomic Stability

摘要:
自闭症临床表现为行为障碍,存在着免疫异常、氧化应激改变甚至基因异常。自闭症患儿普遍存在着维生素D缺乏。维生素D除了传统的钙磷代谢调节作用外,尚具有免疫调节、增加谷胱甘肽的合成及基因稳定等功能。我们最新的研究表明维生素D能够改善自闭症患儿的行为,提示维生素D参与了自闭症的致病过程。本文就维生素D在自闭症中的可能作用的研究进展作一综述。

Abstract: Autism is characterized by abnormal immunology, altered oxidative stress and even genetic ab-normality in addition to behavioral problems. Vitamin D deficiency is ubiquity in children with autism. Vitamin D plays a role in regulating immune, up-regulating glutathione, and controlling genome in addition to traditional action on calcium and phosphate regulation. We recently reported that vitamin D supplementation could improve the behavioral manifestations in autistic child, which illustrated that vitamin D was involved in the pathogenesis of autism. Herein we summarize the research progress of the role of vitamin D in autism.

文章引用: 贾飞勇 , 单 玲 , 冯俊燕 , 王 冰 , 李洪华 , 杜 琳 (2014) 维生素D在自闭症中作用的研究进展。 国际神经精神科学杂志, 3, 21-27. doi: 10.12677/IJPN.2014.34004

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