Review of the ERK5 Signaling Pathway Research
Abstract: Extracellular signal regulated kinase 5 (ERK5) is an important part of mitogen activated protein kinase (MAPK) system, and also is a new signal transduction pathway of MAPK signaling system, which has attracted much attention in recent years. ERK5 can be activated by many stimulating factors and plays an important role in cell survival, proliferation and differentiation. Furthermore, ERK5 is closely related to vascular development and proliferation, and other critical functions. This paper focuses on the origin, structure, property, physiological features of ERK5, and the relation-ship between ERK5 and tumor and non-oncologic diseases, and reviews the research direction in the future.
文章引用: 罗 松 , 苏胜发 , 欧阳伟炜 , 卢 冰 (2014) ERK5信号通路研究现状。 世界肿瘤研究， 4， 41-46. doi: 10.12677/WJCR.2014.44008
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