巨大肾素瘤临床病理学观察一例报告
Clinical Pathological Observation of Giant Reninoma of Kidney: One Case Report

作者: 邢传平 , 史 敏 :兰州军区兰州总医院病理科,兰州;

关键词: 肾素瘤免疫组化超微结构Reninoma Immunohistochemistry Ultra Microstructure

摘要:
目的:探讨肾素瘤的组织病理学特点,做到正确诊断。方法:对肿瘤进行临床和组织病理学、免疫组织化学和超微结构观察。结果:临床表现为重症肾素性高血压伴发严重心衰。镜下瘤细胞生长活跃,核异型性,核分裂像易见,瘤组织灶性变性坏死,浸润包膜。超微结构观察瘤细胞胞质内可见散在或群集的圆形、菱形分泌颗粒。结论:肾素瘤是一种内分泌肿瘤,一般认为来源于肾小球球旁细胞,本例免疫组化提示与血管内皮及神经内分泌有关,外科手术切除后高血压症状得到缓解,愈后好。正确诊断需要光镜、免疫组化与电镜观察相结合。

Abstract: Objective: To elucidate the morphologic features and diagnostic evidence of reninoma of kidney. Methods: The clinic features of the patient were reviewed and the histopathological and ultra-structural features were observed by immunohistochemistry, light and electron microscopes. Re-sults: The patient showed severe renal hypertention and severe heart failure. Under light micro-scope, the tumor showed active proliferation, remarkable heterokaryosis with hyperchromatic, irregular outline and pleomorphic nuclear and more mitosis. The tumor cells showed invasive growth and massive necrosis. Under electron microscope, many dispersed and multitudinous round or diamond granules were seen in the cytoplasm of the tumor cells. Conclusion: The tumor is a kind of endocrine tumor and is considered to be juxtaglomerular call origin. The immunohistochemical results of the reported case suggest that the tumor origin is associated with neuroendocrine and endothelium of vascular. The hypertention-related symptoms disappear after operation and the prognosis of the patient is well. The correct diagnosis needs to unite the light and electron microscopes observation.

Abstract:

Abstract:

文章引用: 邢传平 , 史 敏 (2014) 巨大肾素瘤临床病理学观察一例报告。 亚洲肿瘤科病例研究, 3, 37-40. doi: 10.12677/ACRPO.2014.34008

参考文献

[1] 王保平, 陈光富, 许勇, 等 (2012) 肾素瘤2例. 泌尿外科杂志, 12, 919.

[2] 赵伟, 李辉, 李振华, 等 (2011) 肾素瘤的诊断与治疗: 3例报告. 中国医科大学学报, 9, 1248-1249.

[3] 涂响安, 赵亮, 梁辉, 等 (2010) 肾素瘤的诊断与治疗(附3例报告). 现代泌尿外科杂志, 2, 93-95.

[4] 于洪伟, 王武, 张洪雷 (2011) 肾球旁细胞瘤合并出血1例. 中日友好医院学报, 5, 312-313.

[5] 游燕, 刘静, 张柳, 等 (2012) 肾球旁细胞瘤2例临床病理探讨. 诊断病理杂志, 4, 259-262.

[6] 张瑜, 常桂娟, 周克明, 等 (2012) 肾素瘤1例. 中华临床医师杂志, 23, 7901-7911.

[7] 郭晓蕙 (2009) 肾素瘤的诊治进展. 中国豕实用杂志, 10, 895-897.

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