The Progress in the Study of the Correlation between the WNK1 Gene and Primary Hypertension

作者: 王 莉 :内蒙古医科大学附属医院,呼和浩特; 于赛华 :内蒙古医科大学,呼和浩特;

关键词: 原发性高血压WNK1基因Gordon综合征离子转运Essential Hypertension Wnk1 Gene Gordon Syndrome Iron Transport


Abstract: WNK1 was the first member found in WNK family; it has multiple transcription start sites and dif-ferent transcription products in different tissues. Further researches found that the deletion of Intein-1 in WNK1 gene can lead to Gordon syndrome. WNK1 is a regulatory protein of the renal iron transporters and channels, and plays a very important role in maintaining renal potassium, sodium and chlorine ions balance as well as the regulation of blood pressure, so the WNK1 gene is considered a key genes for essential hypertension. In addition, the WNK1 gene polymorphism may be linked to the susceptibility of the essential hypertension in general population. This review shows the source, structure and function of the WNK1, and investigates the correlation between primary hypertension and WNK1 aimed at guiding anti-hypertensive drugs clinical drug regiments and forecasts.

文章引用: 王 莉 , 于赛华 (2014) WNK1与原发性高血压相关性研究进展。 临床医学进展, 4, 47-52. doi: 10.12677/ACM.2014.43009


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