Vitamin D Supplementation Improves Autistic Symptoms in a Child with Autism Spectrum Disorder
Abstract: Objective: Vitamin D insufficiency and deficiency is recently regarded as one of the environmental factors related with autism spectrum disorders. The aim of this paper is to investigate the possible effect of vitamin D supplementation on autistic behavioral manifestations of a child with autism spectrum disorders. Methods: The clinical data of one case with autism spectrum disorders with vitamin D supplementation in our department was retrospectively analyzed. Result: The child was referred to our department for language delay and unresponsivity to instruction. In view of his clinical manifestation, diagnosis of autism spectrum disorders was made according to DSM-IV. ABC, CARS and M-CHAT-R were used to assess the autistic severity in the clinic. Serum 25(OH) level was 14.3 ng/ml. Vitamin D3 intramuscular injection and oral administration were carried out according to protocol of our clinical trial registration. With a two-month following-up, the autistic symptoms were gradually improved according to clinical manifestation and assessment batteries. Meanwhile, Serum 25(OH) level was 51.8 ng/ml. Conclusion: Vitamin D supplementation may be effective in ameliorating the autistic behavioral problems in children with autism spectrum disorders.
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