Progress in Research on Susceptibility Genes Associated with Noise-Induced Hearing Loss
Abstract: Noise-induced hearing loss (NIHL) is one of the most popular professional diseases across countries. The specific pathogenesis of NIHL is complicated and remains unclear. Now researchers try to understand NIHL with advanced molecular biological technology, which dives deep into gene level. This review will try to find out what researchers have found through years of re- searches.
文章引用: 陈新焰 , 陈福权 (2014) 噪声性耳聋易感基因研究进展。 亚洲耳鼻咽喉科病例研究， 2， 5-9. doi: 10.12677/ACRO.2014.22002
 Alberti, P. (1998) Noise-induced hearing loss—A global problem. In: Luxon, L. and Prasher, D., Eds., Advances in Noise Research, Vol. 1, Protection against noise, Whurr Publisher Ltd., London.
 Lim, D.J. (1986) Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. American Journal of Otolaryngology, 7, 73-99.
 Toppila, E., Pyykko, I.I., Starck, J., Kaksonen, R. and Ishizaki, H. (2000) Individual riskfactors in the de-velopment of noise-induced hearing loss. Noise and Health, 2, 59-70.
 Henderson, D., Bielefeld, E.C., Harris, K.C. and Hu, B.H. (2006) The role of oxidative stress in noise-induced hearing loss. Ear and Hearing, 27, 1-19.
 Fortunato, G., Marciano, E., Zarrilli, F., Mazzaccara, C., Intrieri, M., Calcagno, G., Vitale, D.F., La Manna, P., Saulino, C., Marcelli, V. and Sacchetti, L. (2004) Paraoxonase and superoxide dismutasegene polymorphisms and noise-in- duced hearing loss. Clinical Chemistry, 50, 2012-2018.
 Konings, A.,Van Laer, L., Pawelczyk, M., Carlsson, P.I., Bondeson, M.L., Rajkowska, E., Dudarewicz, A., Vandevelde, A., Fransen, E., Huyghe, J., Borg, E., Sliwinska-Kowalska, M. and Van Camp, G. (2007) Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. Human Molecular Genetics, 16, 1872-1883.
 Liu, Y.M., Li, X.D., Guo, X., Liu, B., Lin, A.H., Ding, Y.L. and Rao, S.Q. (2010) SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers. Disease Markers, 28, 137- 147.
 Wangemann, P. (2002) K1 cycling and the endocochlear potential. Hearing Research, 165, 1-9.
 Van Laer, L., Carlsson, P.I., Ottschytsch, N., Bondeson, M.L., Konings, A., Vandevelde, A., Dieltjens, N., Fransen, E., Snyders, D., Borg, E., Raes, A. and Van Camp, G. (2006) The contribution of genes involved in potassium recycling in the inner ear to noise-induced hearing loss. Human Mutation, 27, 786-795.
 Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M. and Romey, G. (1996) K(V)LQT1 and lsK(minK) proteins associate to form the I(Ks) cardiac potassiumcurrent. Nature, 384, 78-80.
 Lim, H.H., Jenkins, O.H., Myers, M.W., Miller, J.M. and Altschuler, R.A. (1993) Detection of HSP72 synthesis after acoustic overstimulation in rat cochlea. Hearing Research, 69, 146-150.
 Yang, M., Tan, H., Yang, Q., Wang, F., Yao, H., Wei, Q., Tanguay, R.M. and Wu, T. (2006) Associa-tion of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Cell Stress and Chaperones, 11, 233-239.
 Konings, A., Van Laer, L., Michel, S., Pawelczyk, M., Carlsson, P.I., Bondeson, M.L., Rajkowska, E., Dudarewicz, A., Vandevelde, A., Fransen, E., Huyghe, J., Borg, E., Sliwinska-Kowalska, M. and Van Camp, G. (2009) Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. European Journal of Human Genetics, 17, 329-335.