Synthesis of the Sulfoether Intermediates of Prazole Compounds
Abstract: Four derivatives of proton pump inhibitors which have potential therapeutic efficacy of digestive diseases were designed based on the mechanism of action of proton pump inhibitor. These com- pounds can be used as new drug candidates and provide a reference for new drug development. Finally, these sulfoether intermediates were efficiently synthesized by using 2-chloro-4-alkoxy- methylpyridine hydrochloride, mercaptan and sodium methoxide, and the molar ratio of the three ingredients is 1:1.1:2.5. The yields of them are mostly above 80%. The reaction has the advantage of mild conditions and simple operation.
文章引用: 刘善和 , 范芳芳 , 方红新 , 张千峰 (2014) 拉唑类药物中间体硫醚化合物的合成。 有机化学研究， 2， 22-27. doi: 10.12677/JOCR.2014.22004
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