叶酸与出生缺陷关系的研究进展
The Research of the Relationship between Folic Acid and Birth Defect

作者: 祝德营 , 李 勇 :北京大学医学部公共卫生学院营养与食品卫生学系,北京;北京大学医学部公共卫生学院母婴营养研究中心,北京; 戴智勇 :北京大学医学部公共卫生学院母婴营养研究中心,北京;澳优乳业(中国)有限公司,长沙;

关键词: 叶酸出生缺陷婴幼儿Folic Acid Birth Defects Infants

摘要:

叶酸属于B族维生素,是DNA和RNA合成过程中不可缺少的重要物质,在细胞生长、分化、修复和宿主防御等方面扮演重要角色。近年来,叶酸在先天性心脏病、神经管畸形等出生缺陷中的作用越来越受到关注。孕妇在妊娠前和妊娠期增补适量叶酸可有效降低出生缺陷疾病的发生率。本文对叶酸与出生缺陷的关系做一简要综述。

Abstract: Folic acid, a B-vitamin, is required for the synthesis of DNA and RNA, and plays an important role in the cell growth, differentiation, repairmen and host defense. In recent years, more and more studies show that folic acid has an important role in the birth defects such as congenital disease and neural tube defects. It can effectively reduce the risk of having a baby with birth defects when the pregnant women have appropriate dose of folic acid. This article reviews the relationship between folic acid and birth defects.

文章引用: 祝德营 , 戴智勇 , 李 勇 (2014) 叶酸与出生缺陷关系的研究进展。 食品与营养科学, 3, 11-15. doi: 10.12677/HJFNS.2014.32003

参考文献

[1] Blom, H.J. (2009) Folic acid, methylation and neural tube closure in humans. Birth Defects Research Part A: Clinical and Molecular Teratology, 85, 295-302.

[2] Blehaut, H., Mircher, C., Ravel, A., et al. (2010) Effect of leucovorin (folinic acid) on the developmental question of children with Down’s syndrome (trisomy 21) and influence of thyroid status. Plos One, 5, e8394.

[3] Williams, P.J., Bulmer, J.N., Innes, B.A., et al. (2011) Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biology of Reproduction, 84, 1148-1153.

[4] 何晓蓉 (2013) 叶酸补充在出生缺陷一级预防措施中的应用. 求医问药(下半月), 11, 30-31.

[5] 张红, 王芳芳, 郭兴萍 (2012) 山西省六县(市)主要出生缺陷影响因素分析. 中华全科医师杂志, 11, 369-371.

[6] Mosley, B.S., Hobbs, C.A., Flowers, B.S., et al. (2007) Folic acid and the decline in neural tube defects in Arkansas. The Journal of the Arkansas Medical Society, 103, 247-250.

[7] 王珊, 潘新娟, 余增丽 (2012) 妊早期妇女血清叶酸水平与胎儿出生缺陷发病关系的队列研究. 中国妇幼保健, 27, 5266-5268.

[8] 李明辉, 黄雪松, 吴雪艳, 等 (2009) 克拉玛依市0~5岁儿童出生缺陷调查. 中国生育健康杂志, 20, 103-105.

[9] 章艳珍, 章世妹, 胡红喜 (2013) 黄山市0~5岁儿童出生缺陷调查报告. 黄山学院学报, 15, 103-106.

[10] Wilson, R.D., Davies, G., Desilets, V., et al. (2003) The use of folic acid for the prevention of neural tube defects and other congenital anomalies. Journal of Obstetrics and Gynaecology Canada, 25, 959-973.

[11] 谢华, 任玉秀, 梁晋魁, 等 (2010) 孕妇血清叶酸和维生素B12水平与子代神经管畸形发生的关系. 中华围产医学杂志, 13, 303-306.

[12] 高光清, 卢晓琳, 白继保, 等 (2010) 妊娠神经管畸形孕妇血清叶酸与同型半胱氨酸水平分析. 中国妇幼保健, 3, 1903-1905.

[13] 高宝英, 吴丽华, 刘清爱 (2009) 孕妇血清叶酸、同型半胱氨酸水平与胎儿神经管畸形危险性研究. 中国生育健康杂志, 20, 200-203.

[14] Berry, R.J. and Li, Z. (2002) Folic acid alone prevents neural tube defects: Evidence from the China study. Epidemiology, 13, 114-116.

[15] Stevenson, R.E., Allen, W.P., Pai, G.S., et al. (2000) Decline in prevalence of neural tube defects in a high-risk region of the United States. Pediatrics, 106, 677-683.

[16] Simmons, C.J., Mosley, B.S., Fulton-Bond, C.A., et al. (2004) Birth defects in Arkansas: Is folic acid fortification making a difference. Birth Defects Research Part A: Clinical and Molecular Teratology, 70, 559-564.

[17] Says, A.-R., Pattinson, D.B.R., Nixon, J., et al. (2008) Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa birth defects research part A. Clinical and Molecular Teratology, 82, 211-216.

[18] Li, D., Pickell, L., Liu, Y., Wu, Q., Cohn, J.S. and Rozen, R. (2005) Matemal methy lenetetrahy drofolate reductase deficiency and low dietary folate in mice. The American Journal of Clinical Nutrition, 82, 188-195.

[19] Shaw, G.M., Zhu, H., Lammer, E.J., Yang, W. and Finnell, R.H. (2003) Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects. American Journal of Epidemiology, 58, 747-752.

[20] Botto, L.D., Mulinare, J. and Erickson, J.D. (2000) Occurrence of congenital heart defects in relation to maternal mulitivitamin use. American Journal of Epidemiology, 151, 874-884.

[21] Botto, L.D., Mulinare, J. and Erickson, J.D. (2003) Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps. American Journal of Medical Genetics Part A, 121A, 95-101.

[22] 李勇 (2005) 叶酸、维生素B12与人类常见出生缺陷的发生及远期影响. 达能营养中心第八次学术年会会议论文集, 24-31.

[23] Wilcox, A.J., Lie, R.T., Solvoll, K., et al. (2007) Folic acid supplements and risk of facial clefts: National population based case-control study. BMJ, 334, 464-470.

[24] Canfield, M.A., Collins, J.S., Botto, L.D., et al. (2005) Changes in the birth prevalence of selected birth defects after a muti-state population-based study. Birth Defects Research Part A: Clinical and Molecular Teratology, 73, 679-689.

[25] Munger, R.G., Sauberlich, H.E., Corcoran, C., et al. (2004) Maternal Vitamin B6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Research Part A: Clinical and Molecular Teratology, 70, 464-471.

[26] Bower, C., Miller, M., Payne, J., et al. (2006) Folate intake and the birth primary prevention of non-neural birth defects. Aus-tralian and New Zealand Journal of Public Health, 30, 258-261.

[27] James, S.J., Pogribna, M., Pogribny, I.P., et al. (1999) Abnormal folate metabolism and mutation in the methylenetra hydro folate reductase gene may be maternal risk factors for Down syndrome. The American Journal of Clinical Nutrition, 70, 495-501.

[28] 陈基强, 李运芳 (2013) 胎儿脐膨出的产前超声检查价值分析. 吉林医学, 34, 1219-1220.

[29] 王维林 (2006) 先天性肛门直肠畸形基础与临床研究. 继续医学教育, 20, 22-24.

[30] Myer, M.F., Li, S., Correa, V.A., et al. (2001) Folic acid supplementation and risk for imperforate anus in China. American Journal of Epidemiology, 154, 1051-1056.

分享
Top