Recent Progress in the Study of Leptin and Its Scientific Significance
Abstract: Leptin is a protein mainly secreted by the lipocyte, which is related to the regulation of food intake, energy expenditure and fat storage closely. Currently, the theory that leptin resistance is a primary risk factor for obesity has been accepted widely. But the clear mechanism has not been clarified yet. The occurrence of leptin resistance may be related to some hypotheses, such as leptin receptor mutation, leptin transshipment, leptin signal suppression, vascular defects and conversion defects. The researchers from all over the world are trying to discover the mechanism based on these hypotheses and are expecting to cure the obesity completely. This review 1) briefly introduces the gene expression and the molecular structure of leptin and leptin receptor; 2) analyzes the signal transduction of leptin such as JAK/STAT, Ras and MAPK; 3) summarizes the access of leptin resistance. Maybe the work will have the certain reference value to the obesity research in the mechanisms of leptin resistance.
文章引用: 高文荣 , 张 浩 , 姜文秀 , 朱万龙 (2014) 瘦素研究的最新进展和科学意义。 生物过程， 4， 1-10. doi: 10.12677/BP.2014.41001
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