尿素通道蛋白B的转运特性
Transport Characteristics of Urea Transporter-B

作者: 钟丹丹 , 杨宝学 :天然药物及仿生药物国家重点实验室,北京大学基础医学院药理学系,北京;

关键词: 尿素通道蛋白B尿素尿素类似物NH3UT-B Urea Urea Analogues Ammonia Water

摘要:
尿素通道蛋白B(urea transporters B, UT-B)主要表达在红细胞和一些上皮及内皮细胞膜,介导尿素的跨膜转运。近年来研究发现UT-B亦参与其他物质的转运,如水、NH3和尿素类似物等,提示UT-B还可以作为水和气体通道。本文主要阐述UT-B对这些物质的转运特性,并探究其可能的生理学意义
Urea transporter UT-B is highly expressed in the membrane of erythrocytes and some epithelial and endothelial cells, in which UT-B facilitates urea transport. Recently, studies find that water, ammonia and urea analogues can also be transported by UT-B. This review mainly focuses on the transport characteristics of UT-B, and the possible physiological significance will be discussed as well.

文章引用: 钟丹丹 , 杨宝学 (2014) 尿素通道蛋白B的转运特性。 生理学研究, 2, 1-4. doi: 10.12677/JPS.2014.21001

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