Z-DNA与人类疾病
Z-DNA and Human Diseases

作者: 周文琪 , 陈诗哲 , 马天骏 :南方医科大学第一临床医学院八年制,广州; 李金明 , 郭艳芳 :南方医科大学基础医学院生物信息学系,广州;

关键词: Z-DNAZ-DNA结合蛋白人类疾病基因调控Z-DNA Z-DNA Binding Protein Human Disease Gene Regulation

摘要:
Z-DNA1979年被Rich等人发现,它处于高能状态而不稳定,不同于传统的B-DNAZ-DNA以其特殊的构象和重要生物学功能越来越受到人们关注,与其作用相关的Z-DNA结合蛋白也备受关注。Z-DNA有其特殊的序列和形成条件,其重要生物学功能也逐渐被揭开面纱,在基因调控、肿瘤发生与病毒感染中都有重要作用。

Abstract:
Z-DNA structure was found by Rich et al. in 1979. Being different from the common B-DNA structure, Z-DNA has its own special conformation and biological functions, and the research on Z-DNA arrests more and more attentions in the recent years. It has been reported that Z-DNA plays important roles in gene regulation, tumor pathogenesis and viral infections.

文章引用: 周文琪 , 陈诗哲 , 马天骏 , 李金明 , 郭艳芳 (2014) Z-DNA与人类疾病。 生物医学, 4, 17-21. doi: 10.12677/HJBM.2014.42003

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