Z-DNA and Human Diseases
Abstract: Z-DNA structure was found by Rich et al. in 1979. Being different from the common B-DNA structure, Z-DNA has its own special conformation and biological functions, and the research on Z-DNA arrests more and more attentions in the recent years. It has been reported that Z-DNA plays important roles in gene regulation, tumor pathogenesis and viral infections.
文章引用: 周文琪 , 陈诗哲 , 马天骏 , 李金明 , 郭艳芳 (2014) Z-DNA与人类疾病。 生物医学， 4， 17-21. doi: 10.12677/HJBM.2014.42003
 Wang, G. and Vasquez, K.M. (2007) Z-DNA, an active element in the genome. Frontiers in Bioscience, 12, 44244438.
 Du, Y and Zhou, X. (2013) Targeting non-B-form DNA in living cells. The Chemical Record, 13, 371-384.
 Pohl, F.M., Jovin, T.M., Baehr, W. and Holbrook, J.J. (1972) Ethidium bromide as a cooperative effector of a DNA structure. Proceedings of the National Academy of Sciences of the United States of America, 69, 3805-3809.
 Wang, A.H., et al. (1979) Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature, 282, 680-686.
 Boyer, A.S., Grgurevic, S., Cazaux, C. and Hoffmann J.S. (2013) The human specialized DNA polymerases and non-B DNA: Vital relationships to preserve genome integrity. Journal of Molecular Biology, 425, 4767-4781.
 Geng, J. and Qu, X. (2010) Recent progress report on DNA BZ transition modulated by rare earth-amino acid complex and Alzheimer's disease amyloid beta. Journal of Rare Earths, 28, 820-823.
 Malfoy, B., et al. (1986) Nucleotide sequence of an heterochromatic segment recognized by the antibodies to Z-DNA in fixed metaphase chromosomes. Nucleic Acids Research, 14, 3197-3114.
 Feng, L., et al. (2013) Lighting up left-handed Z-DNA: Photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations. Nucleic Acids Research, 41, 7987-7996.
 Qu, X., et al. (2000) Allosteric, chiral-selective drug binding to DNA. Proceedings of the National Academy of Sciences of the United States of America, 97, 12032-12037.
 Ha, S.C., et al. (2005) Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. Nature, 437, 1183-1186.
 Doluca, O., Withers, J.M. and Filichev, V.V. (2013) Molecular engineering of guanine-rich sequences: Z-DNA, DNA triplexes, and G-quadruplexes. Chemical Reviews, 113, 3044-3083.
 Feigon, J., et al. (1985) Z-DNA forms without an alternating purine-pyrimidine sequence in solution. Science, 230, 82-84.
 Schroth, G.P., Chou, P.J. and Ho, P.S. (1992) Mapping Z-DNA in the human genome. Computer-aided mapping reveals a nonrandom distribution of potential Z-DNA-forming sequences in human genes. The Journal of Biological Chemistry, 267, 11846-11855.
 Garner, M.M. and Felsenfeld, G. (1987) Effect of Z-DNA on nucleosome placement. Journal of Molecular Biology, 196, 581-590.
 Liu, R., Liu, H., Chen, X., Kirby, M., Brown, P.O. and Zhao, K. (2001) Regulation of CSF1 promoter by the SWI/ SNF-like BAF complex. Cell, 106, 309-318.
 Nie, Y., Ding, L., Kao, P.N., Braun, R. and Yang, J.H. (2005) ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Molecular and Cellular Biology, 25, 6956-6963.
 Barraud, P. and Allain, F.H. (2012) ADAR proteins: Double-stranded RNA and Z-DNA binding domains. Current Topics in Microbiology and Immunology, 353, 35-60.
 Peck, L.J. and Wang, J.C. (1985) Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence. Cell, 40, 129-137.
 Wang, G., Christensen, L.A. and Vasquez, K.M. (2006) Z-DNA-forming sequences generate large-scale deletions in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America, 103, 2677-2682.
 Yang, L., Wang, S., Tian, T. and Zhou, X. (2012) Advancements in Z-DNA: Development of inducers and stabilizers for B to Z transition. Current Medicinal Chemistry, 19, 557-568.
 Treco, D. and Arnheim, N. (1986) The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis. Molecular and Cellular Biology, 6, 39343947.
 Leng, M. (1985) Left-handed Z-DNA. Biochimica et Biophysica Acta, 825, 339-344.
 Thomas, T.J. and Thomas, T. (1994) Polyamine-induced Z-DNA conformation in plasmids containing (dA-dC)n.(dGdT)n inserts and increased binding of lupus autoantibodies to the Z-DNA form of plasmids. Biochemical Journal, 298, 485-491.
 Suram, A., Rao, K.S., Latha, K.S. and Viswamitra, M.A. (2002) First evidence to show the topological change of DNA from B-dNA to Z-DNA conformation in the hippocampus of Alzheimer’s brain. Neuromolecular Medicine, 2, 289-297.
 Geng, J., Zhao, C, Ren, J. and Qu, X. (2010) Alzheimer’s disease amyloid beta converting left-handed Z-DNA back to right-handed B-form. Chemical communications (Cambridge, England), 46, 7187-7189.
 Hardy, J. and Selkoe, D.J. (2002) The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science, 297, 353-356.
 Hegde, M.L., et al. (2004) First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: A new insight in understanding Alzheimer’s disease. Journal of Molecular Neuroscience, 22, 19-31.
 Thandla, S.P., et al. (1999) ETV6-AML1 translocation breakpoints cluster near a purine/pyrimidine repeat region in the ETV6 gene. Blood, 93, 293-299.