The p38 Mitogen-Activated Protein Kinase Pathway in Rheumatoid Arthritis
Abstract: Rheumatoid arthritis processes are based on a sustained regulated communication network among different cells types. This network comprises extracellular mediators such as cytokines, chemokines and matrix degrading proteases, which orchestrate the participation of cells in the chronic inflammatory process. Intracellular transcription factor pathways are corresponding with this outside communication world, which transfer information about inflammatory stimuli to the cell nucleus. This review examines the function of one key signal transduction pathway of inflammation—the p38 mitogen-activated protein kinases (p38 MAPK). The p38 MAPK signalling pathway is considered crucial for the induction and maintenance of chronic inflammation, and thus its components emerge as interesting molecular targets of small molecule inhibitors for controlling inflammation. This review not only summarizes the current knowledge of activation, regulation and function of the p38 MAPK pathway but also examines the role of this pathway in rheumatoid arthritis.
文章引用: 陈缙筠 , 吴 虹 , 李 辉 , 代苗苗 , 胡顺莉 , 陈 建 (2014) p38 MAPK通路的活性调控及其在类风湿性关节炎中的作用。 药物资讯， 3， 8-12. doi: 10.12677/PI.2014.31003
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